A partir d’une revue systématique de la littérature (14 études, 1 660 patients), cette étude analyse l’efficacité des interventions à base de conseils nutritionnels et/ou de promotion de l’activité physique pour améliorer la qualité de vie chez des patients âgés de plus de 60 ans, atteints d’un cancer ou ayant survécu à la maladie

Physical activity and nutrition interventions for older adults with cancer: a systematic review

Cynthia C. Forbes, Flavia Swan, Sarah L. Greenley (et al.)

Purpose :The aim of this review was to summarize the current literature for the effectiveness of activity and nutritional based interventions on health-related quality of life (HRQoL) in older adults living with and beyond cancer (LWBC). Methods : We conducted systematic structured searches of CINAHL, Embase, Medline, Cochrane CENTRAL databases, and bibliographic review. Two independent researchers selected against inclusion criteria: (1) lifestyle nutrition and/or activity intervention for [...]

Menée aux Etats-Unis à partir de données portant sur 720 témoins et sur 12 123 patients ayant survécu 5 ans à un cancer pédiatrique diagnostiqué entre 1970 et 1999 (âge médian au diagnostic : 7 ans ; durée médiane de suivi depuis le diagnostic : 16 ans), cette étude analyse l’association entre l’intensité d’une activité physique et la survenue de troubles neurocognitifs

Consistent Physical Activity and Future Neurocognitive Problems in Adult Survivors of Childhood Cancers: A Report From the Childhood Cancer Survivor Study

Emily Barlow-Krelina, Yan Chen, Yutaka Yasui (et al.)

PURPOSE : To investigate longitudinal associations between physical activity (PA) and neurocognitive problems in adult survivors of childhood cancer. METHODS : A total of 12,123 5-year survivors diagnosed between 1970 and 1999 (median [range] age at diagnosis, 7 [0-21] years, time since diagnosis at baseline, 16 [6-30] years) and 720 siblings self-reported PA and neurocognitive problems. PA was collected at baseline, and PA and neurocognitive data were obtained 7 (1-12) years and 12 (9-14) [...]

Mené aux Etats-Unis sur 160 patients ayant survécu à un cancer et souffrant d’insomnie, cet essai randomisé compare l’efficacité, du point de vue de l’amélioration de leurs fonctions cognitives, d’une intervention à base d’acupuncture et d’une psychothérapie comportementale

Effects of acupuncture versus cognitive behavioral therapy on cognitive function in cancer survivors with insomnia: A secondary analysis of a randomized clinical trial

Kevin T. Liou, James C. Root, Sheila N. Garland (et al.)

Background : Cancer?related cognitive impairment is a prevalent, disruptive condition potentially exacerbated by sleep disturbances. The current study was performed to evaluate the effects of acupuncture versus cognitive behavioral therapy for insomnia (CBT?I) on objective and subjective cognitive function in cancer survivors with insomnia. Methods : Using data from a randomized clinical trial (160 survivors) that compared acupuncture versus CBT?I for insomnia occurring in cancer survivors, the [...]

A partir d’une revue systématique de la littérature (10 essais randomisés, 632 patients), cette méta-analyse évalue l’intérêt d’interventions utilisant de la musique pour réduire la sévérité des nausées et vomissement induits par la chimiothérapie chez des patients atteints d’un cancer

Music interventions for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis

Ting-ting Wei, Xu Tian, Fang-yuan Zhang, Wan-min Qiang (et al.)

Background : Chemotherapy-induced nausea and vomiting (CINV) is the most common and severe side effects brought by chemotherapeutics. The role of music interventions in relieving CINV is uncertain. The aim of this systematic review was to test the effects of music interventions on three categories of CINV. Methods : A systematic search was conducted in Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, EMBASE, [...]

Menée à partir de données portant sur 784 adultes atteints d’une leucémie lymphoblastique aiguë Ph- diagnostiquée entre 2006 et 2014, cette étude analyse l’efficacité d’une stratégie prophylactique par supplémentation en antithrombine pour réduire le risque de thromboembolie

Thromboembolism Prophylaxis in Adult Patients with Acute Lymphoblastic Leukemia Treated in the GRAALL-2005 Study

Corentin Orvain, Marie Balsat, Emmanuelle Tavernier (et al.)

Patients undergoing treatment for acute lymphoblastic leukemia (ALL) are at risk for thrombosis, in part due to the use of L-asparaginase (L-ASP). Antithrombin (AT) replacement has been suggested to prevent VTE and thus might increase exposure to ASP. We report herein the results of the prophylactic replacement strategy in the pediatric-inspired prospective GRAALL-2005 study. Between 2006 and 2014, 784 adult patients with newly diagnosed Philadelphia-negative ALL were included. The incidence [...]

Mené par enquête auprès de 794 enfants et adolescents atteints d’une leucémie lymphoblastique aiguë, cet essai prospectif évalue les effets d’une consommation d’antioxydants d’origine alimentaire sur la réduction des toxicités liées aux traitements anticancéreux et sur la survie

Protective Effects of Dietary Intake of Antioxidants and Treatment-Related Toxicity in Childhood Leukemia: A Report From the DALLT Cohort

Elena J. Ladas, Traci M. Blonquist, Maneka Puligandla (et al.)

PURPOSE : The benefits and risks of supplementation with antioxidants during cancer therapy have been a controversial area. Few studies have systematically evaluated dietary intake of antioxidants with toxicity and survival in childhood cancer. We sought to determine the role of dietary intake of antioxidants on rates of infections, mucositis, relapse, and disease-free survival during induction and postinduction phases of therapy among children and adolescents with acute lymphoblastic leukemia [...]

Menée au Canada par questionnaire auprès de 426 patientes atteintes d’un cancer du sein, cette étude prospective analyse les facteurs associés à la douleur avant, pendant et après une radiothérapie adjuvante

Self-reported pain in breast cancer patients receiving adjuvant radiotherapy

Emily Lam, Gina Wong, Liying Zhang, Leah Drost (et al.)

Purpose : Breast cancer patients receiving radiotherapy (RT) commonly report pain, contributing to physical and emotional distress, and potentially resulting in poor quality of life. This study prospectively identified trends and risk factors in patient-reported pain associated with breast irradiation using the Edmonton Symptom Assessment Scale (ESAS) and a study-specific Skin Symptom Assessment (SSA). Methods : Before RT and once per week during RT, patients completed the ESAS and SSA. Upon RT [...]

Menée aux Etats-Unis auprès de 267 patientes atteintes d’un cancer du sein de stade précoce traité par chimiothérapie (âge médian : 58 ans), cette étude compare la sévérité des symptômes induits par le traitement anticancéreux déclarée par les patientes et celle constatée par le médecin

Congruence of patient and clinician reported toxicity in women receiving chemotherapy for early breast cancer

Kirsten A. Nyrop, Allison M. Deal, Bryce B. Reeve (et al.)

Background : The National Cancer Institute's Patient?Reported Outcomes Version of the Common Terminology Criteria for Adverse Events, collected alongside the clinician?reported Common Terminology Criteria for Adverse Events, enables comparisons of patient and clinician reports on treatment toxicity. Methods : In a multisite study of women receiving chemotherapy for early?stage breast cancer, symptom reports were collected on the same day from patients and their clinicians for 17 symptoms; their [...]

Menée en Italie pendant la crise sanitaire liée à la pandémie de COVID-19, cette étude présente deux cas de patients atteints d’un cancer du poumon, présentant une suspicion d’infection par le Coronavirus et traités par inhibiteurs de ALK/ROS1, et discute des enjeux liés à leur prise en charge

COVID-19 in lung cancer patients receiving ALK/ROS1 inhibitors

Alessandro Leonetti, Francesco Facchinetti, Teresa Zielli (et al.)

Since December 2019, an increasing number of coronavirus disease-19 (COVID-19) cases have been reported all around the globe following the outbreak of the pandemic acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection [1]. To date, COVID-19 lacks a specific treatment to counteract the onset of SARS and subsequent multiorgan failure, whose evolution is usually rapid and severe. Liang and collaborators recently described an increased risk of COVID-19 among patients with cancer, which is [...]

Menée en Irlande du Nord à partir de données portant sur 19 types de cancers diagnostiqués sur la période 1993-2017, cette étude présente des projections d’incidence de la maladie jusqu’en 2040

Cancer incidence projections in Northern Ireland to 2040

David W Donnelly, Lesley A. Anderson, Anna Gavin

Background: Data on historical trends and estimates of future cancer incidence are essential if cancer services are to be adequately resourced in future years. Methods: Age-standardised incidence rates for all cancers combined and 19 common cancers diagnosed during 1993-2017 were determined by sex, year of diagnosis and age. Data were fitted using an age-period-cohort model, which was used to predict rates in future years up to 2040. These were combined with population projections to provide [...]

Cet article propose des stratégies pour diagnostiquer et traiter une éventuelle infection par le coronavirus chez des patients atteints d’un cancer pendant la crise sanitaire liée à la pandémie du COVID-19 en Chine

Prevention and control strategies for the diagnosis and treatment of cancer patients during the COVID-19 pandemic

Juan Tan, Chao Yang

COVID-19 has had a major impact worldwide due to its high infectiousness. Patients with cancer are more susceptible to infection and more likely to have severe events than other patients. This paper proposes management strategies for cancer patients that are beneficial for pandemic control and reduce the impact of the pandemic on cancer patients.

Cet article discute des enjeux liés aux traitements anticancéreux dispensés aux patients atteints d’un cancer pendant la crise sanitaire liée à la pandémie du COVID-19

Effect of the COVID-19 pandemic on cancer treatment and research

Kamal S Saini, Begoña de las Heras, Javier de Castro (et al.)

The coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly escalated into a global pandemic. Patients with haematological and other cancers,1, 2 and recipients of haematopoietic stem cell transplantation (HSCT), could be at particular risk from COVID-19, since they tend to be older, have multiple comorbidities, and are often immunosuppressed by their disease or therapy. A retrospective analysis of 355 patients who died [...]

Cet article américain discute des enjeux liés à la prise en charge, pendant la crise sanitaire liée à la pandémie du COVID-19, des besoins spécifiques des patients ayant survécu à un cancer

Addressing the needs of cancer survivors during the COVID-19 pandemic

Larissa Nekhlyudov, Saskia Duijts, Shawna V. Hudson (et al.)

The recent COVID-19 pandemic has affected the world and has the potential to disproportionately affect and disrupt the lives of cancer survivors, including those currently in treatment, those who have completed treatment, and those who are now living cancer-free. There are currently over 17 million cancer survivors in the USA [1] and millions more around the world [2, 3]. Much has been published over the past several decades about the late and long-term effects of cancer treatment, alongside [...]

Cet article discute des enjeux liés à la prise en charge des patients atteints d’un cancer pendant la crise sanitaire liée à la pandémie de COVID-19 aux Etats-Unis

Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer

Philippe E. Spiess, John Greene MD, Robert J. Keenan (et al.)

The alarming situation of the 2019 novel coronavirus disease (COVID?19) is contrasted by the limited efforts to curb the spread and impact of the disease among patients with cancer. This commentary proposes a simple 5?part strategy plus rapidly expanded use of telemedicine to anticipate and deal with COVID?19 and, by extension, future epidemics in patients with cancer. Deaths from the 2019 novel coronavirus disease (COVID?19) are heavily skewed to the elderly, with almost all of the deaths [...]

Menée à partir de données 1998-2012 provenant de 41 pays et portant sur 1 846 588 adolescents et jeunes adultes atteints d’un cancer, cette étude analyse les facteurs associés à l’évolution de l’incidence de la maladie

International Trends in the Incidence of Cancer Among Adolescents and Young Adults

Sumit Gupta, Andrew Harper, Yibing Ruan (et al.)

Background : Although adolescent and young adult (AYA) cancers represent a unique spectrum of malignancies, epidemiological studies of cancer incidence often group AYAs together with younger or older populations, obscuring patterns specific to this population. Methods : We examined AYA cancer incidence trends in 41 countries over a 15-year period using the CI5plus database. Truncated age-standardized incidence rates were calculated and the annual percentage change was assessed, with statistical [...]

A partir d’une revue systématique de la littérature publiée entre 2010 et 2018 (5 articles), cette étude analyse les facteurs associés à un défaut d’adhésion aux traitements anticancéreux dispensés par voie orale chez des patients atteints d’un cancer

A review of factors influencing non-adherence to oral antineoplastic drugs

Xiomara Skrabal Ross, Kate M. Gunn, Vijayaprakash Suppiah (et al.)

Purpose : Adherence to oral antineoplastic drugs is a complex phenomenon, and knowledge about the reasons that people with cancer do not adhere to their prescriptions is essential to inform adherence-related support in clinical and research contexts. This study aims to provide an up-to-date summary of the key reasons for non-adherence to oral antineoplatic drugs (OAD) in people with cancer. Methods : Electronic databases Medline, Embase, Emcare, and PsychINFO were searched for systematic [...]

Cet article présente la stratégie mise en place dans un centre hospitalier en Allemagne pour prendre en charge les patients atteints d’un cancer génito-urinaire de stade métastatique pendant la crise sanitaire liée à la pandémie de COVID-19

Lessons from the COVID-19 pandemic – will virtual patient management reshape uro-oncology in Germany?

Severin Rodler, Maria Apfelbeck, Christian Stief (et al.)

The Coronavirus disease (COVID-19) pandemic is challenging for physicians treating patients with genitourinary cancers as those are considered at high risk for severe events. The uro-oncology outpatient clinic at our academic institution was affected early by the outbreak due to the widespread infection of health care personnel. Subsequently, we developed a strategy to ensure patient’s safety by efforts focused on strict quarantine observation, reduction of clinic visits and implementation of [...]

Menée à partir de données de 10 registres portant sur 21 990 patientes atteintes d’un cancer du col de l’utérus, cette étude analyse les facteurs associés à l’évolution de l’incidence de la maladie dans des pays d’Afrique sub-saharienne (Gambie, Kenya, Malawi, Maurice, Seychelles, Afrique du Sud, Ouganda, Zimbabwe) sur une période de 10 à 25 ans

Trends in cervical cancer incidence in sub-Saharan Africa

Elima Jedy-Agba, Walburga Yvonne Joko, Biying Liu (et al.)

Background : Cervical cancer is the second most common cancer and the leading cause of cancer death in women in sub-Saharan Africa (SSA). Methods : Trends in the incidence of cervical cancer are examined for a period of 10–25 years in 10 population-based cancer registries across eight SSA countries (Gambia, Kenya, Malawi, Mauritius, Seychelles, South Africa, Uganda and Zimbabwe). A total of 21,990 cases of cervical cancer were included in the analyses. Results : Incidence rates had increased in [...]

Menée en Allemagne par questionnaire auprès de 59 patients atteints d’une leucémie aiguë, cette étude analyse, avant une greffe allogénique de cellules souches hématopoïétiques, les facteurs associés à leur peur de la progression de la maladie

Fear of disease progression and relevant correlates in acute leukemia patients prior to allogeneic hematopoietic stem cell transplantation

Sandra Thiele, Simone Goebel, Nicolaus Kröger (et al.)

Objective : Prior to hematopoietic stem cell transplantation (HSCT), and despite the high objective risks associated with HSCT, fear of progression (FoP) has only sparsely been studied in patients with acute leukemia until now. The aim of this study was the assessment of the prevalence of FoP, and any relevant correlates and typical concerns. Methods : We included 59 adult patients with acute leukemia who were tested prior to their first HSCT during an in?patient stay. Patients completed [...]

Menée aux Etats-Unis par enquête auprès de 7 988 patientes ayant survécu à un cancer du sein (âge moyen : 67,2 ans), cette étude analyse l’association entre une consommation de fruits et de légumes et la détresse psychologique

Fruit and vegetable consumptions in relation to frequent mental distress in breast cancer survivors

Dongyu Zhang, Yilin Feng, Nan Li & Xuezheng Sun (et al.)

Purpose : Evidence suggests that fruit and vegetable consumptions may improve mental health among general population. However, their associations among breast cancer survivors are unclear. We planned to investigate this association via a nationwide survey in the USA. Methods : We identified 7988 breast cancer survivors from 2009 Behavioral Risk Factor Surveillance System (BRFSS). Fruit juice, fruit, and vegetable consumptions were categorized as ordinal variables to approximate tertiles. [...]

Menée aux Etats-Unis à partir de données 2004-2013 portant sur 181 784 patients atteints d’un cancer du poumon à petites cellules, cette étude analyse l’effet de la couverture médicale Medicaid sur la survie

Association of Medicaid Insurance With Survival Among Patients With Small Cell Lung Cancer

Todd A. Pezzi, David L. Schwartz, Katherine M. W. Pisters (et al.)

Importance : Small cell lung cancer (SCLC) is an aggressive neoplasm requiring rapid access to subspecialized multidisciplinary care. For this reason, insurance coverage such as Medicaid may be associated with oncologic outcomes in this disproportionately economically vulnerable population. With Medicaid expansion under the Affordable Care Act, it is important to understand outcomes associated with Medicaid coverage among patients with SCLC. Objective : To determine the association of Medicaid [...]

Menée aux Etats-Unis auprès de 126 patients ayant survécu 2 ans à un cancer pédiatrique, cette étude analyse l’intérêt d’un "passeport santé" sous forme d’une carte de crédit et distribué à l’issue de leur première visite de suivi, pour améliorer leurs connaissances sur la maladie (diagnostic, traitements et effets indésirables, soins de suivi)

A portable survivorship care plan: a tool that helps educate and improve knowledge in childhood cancer survivors

Patricia Murphy, Alyssa Levine, Tanya Lerma (et al.)

Purpose : There is a growing population of survivors of childhood cancer at risk for late effects that can affect their overall quality of life. There is evidence that they have inadequate knowledge about their diagnosis, treatment, and subsequent late effects. A randomized study was conducted to determine if a portable credit card–sized plastic card, the “Survivor Healthcare Passport,” improved the survivor’s knowledge of diagnosis, treatment, risks, and follow-up care. The study included 126 [...]

Menée aux Etats-Unis auprès d’un panel d’experts (39 participants), cette étude identifie les axes prioritaires pour développer des soins de suivi personnalisés chez des patients ayant survécu à un cancer

Personalized Cancer Follow-Up Care Pathways: A Delphi Consensus of Research Priorities

Corinne R Leach, Catherine M Alfano, Jessica Potts (et al.)

Development of personalized, stratified follow-up care pathways where care intensity and setting vary with needs could improve cancer survivor outcomes and efficiency of healthcare delivery. Advancing such an approach in the United States requires identification and prioritization of the most pressing research and data needed to create and implement personalized care pathway models. Cancer survivorship research and care experts (N?=?39) participated in an in-person workshop on this topic in [...]