Menée aux Etats-Unis à l'aide de données portant sur 398 patients atteints d'un syndrome myélodysplasique et sur 698 témoins, cette étude analyse l'association entre une consommation d'alcool et le risque de développer la maladie, par sous-type et en fonction du sexe

Alcohol use is not a significant contributor to myelodysplastic syndromes

Duffy, Elizabeth A. ; Nguyen, Phuong L. ; Cioc, Adina ; Warlick, Erica ; Roesler, Michelle A. ; Poynter, Jenny N.

Purpose: Myelodysplastic syndromes (MDS) are a class of clonal neoplastic disorders of largely unknown etiology, and published data remain inconclusive regarding the association between lifetime alcohol consumption and MDS risk. In these analyses, data from a population-based case–control study were used to investigate this association. Methods: Eligible cases of MDS were identified through the Minnesota Cancer Reporting System; controls were matched by sex and age-decile. A central review [...]

Menée aux Etats-Unis par questionnaire auprès de 494 860 participants (durée de suivi : 16 ans), cette étude analyse l'association entre l'apport total en micronutriments impliqués dans le métabolisme monocarboné et le risque de carcinome hépatocellulaire (647 cas)

One-Carbon Metabolism–Related Micronutrients Intake and Risk for Hepatocellular Carcinoma: A Prospective Cohort Study

Antwi, Samuel O. ; Petrick, Jessica L. ; Campbell, Peter T. ; Norez, Daniel A. ; Stevens, Victoria L. ; Liao, Linda M. ; Roberts, Lewis R. ; Patel, Tushar ; McGlynn, Katherine A.

Deficient intake of micronutrients involved in one-carbon metabolism (e.g., choline, methionine, vitamin B12, and folic acid) leads to hepatocellular carcinoma (HCC) development in rodents, but it is under-investigated in humans. We investigated the association between one-carbon metabolism–related micronutrient intake and HCC risk in a prospective cohort of 494,860 participants with 16 years of follow-up in the NIH-AARP study. Dietary intakes and supplement use were ascertained at baseline [...]

A partir d'une recherche systématique de la littérature publiée jusqu'à fin décembre 2018 (25 études), cette méta-analyse évalue le risque de cancer chez les pompiers selon les époques et les régions

Cancer risks of firefighters: a systematic review and meta-analysis of secular trends and region-specific differences

Casjens, Swaantje ; Brüning, Thomas ; Taeger, Dirk

Purpose: The objective of this study was to conduct a systematic review and meta-analysis to evaluate the cancer risks among firefighters in the time course and from different geographical areas. Method: A PubMed search was performed to identify cohort studies about cancer risk and firefighting presented with standardized incidence ratios (SIRs) or standardized mortality ratios (SMRs). Using random-effect models, meta-relative risk estimates (mSIRs, mSMRs) and 95% confidence intervals (CI) were [...]

Menée aux Etats-Unis à partir de données portant sur plus de 2 000 personnes, cette étude évalue le rôle du type d'habitation à la naissance dans l'association entre une exposition résidentielle aux champs magnétiques et le risque de leucémie pédiatrique

The role of dwelling type when estimating the effect of magnetic fields on childhood leukemia in the California Power Line Study (CAPS)

Amoon, A. T. ; Crespi, C. M. ; Nguyen, A. ; Zhao, X. ; Vergara, X. ; Arah, O. A. ; Kheifets, L.

Purpose: The type of dwelling where a child lives is an important factor when considering residential exposure to environmental agents. In this paper, we explore its role when estimating the potential effects of magnetic fields (MF) on leukemia using data from the California Power Line Study (CAPS). In this context, dwelling type could be a risk factor, a proxy for other risk factors, a cause of MF exposure, a confounder, an effect-measure modifier, or some combination. Methods: We obtained [...]

Menée à partir de données de l'assurance maladie coréenne portant sur 4 558 376 femmes ménopausées ayant réalisé un dépistage du cancer du sein entre 2009 et 2014 (durée médiane de suivi : 5,35 ans), cette étude identifie des facteurs faisant varier l'association entre un traitement hormonal substitutif et le risque de cancer du sein

Hormone replacement therapy, breast cancer risk factors and breast cancer risk: a nationwide population-based cohort

Yoo, Tae-Kyung ; Han, Kyung-Do ; Kim, Dahye ; Ahn, Juneyoung ; Park, Woo-Chan ; Chae, Byung Joo

Background: Hormone replacement therapy (HRT) increases the risk of breast cancer, but the association may vary according to patient factors. We investigated the association between HRT and breast cancer in a nationwide cohort with risk stratification according to risk factors for breast cancer. Methods: Using the Korean National Health Insurance Service database, 4,558,376 postmenopausal women who underwent breast cancer screening and regular health checkups from 2009 to 2014 were analyzed. [...]

Menée en Suède à l'aide de données portant sur 37 669 hommes nés entre 1946 et 1961 et à partir des données des registres des cancers, cette étude analyse l'association entre l'indice de masse corporelle et la taille pendant l'enfance et à la puberté et le risque de cancer hématologique à l'âge adulte (459 cas)

Childhood Body Mass Index is associated with the risk of adult hematologic malignancies in men - the BEST Gothenburg cohort

Celind, Jimmy ; Ohlsson, Claes ; Bygdell, Maria ; Martikainen, Jari ; Lewerin, Catharina ; Kindblom, Jenny M

Hematologic malignancies are common and the incidence is increasing. Adult obesity has been associated with hematologic malignancies (HM), but the importance of Body Mass Index (BMI) in childhood and during puberty has not been evaluated. The aim with the present study was to evaluate the relative contribution of BMI and height in childhood and during puberty for the risk of adult HM. 37 669 men born in 1946-1961 who had weight and height measured at 8 (childhood) and 20 (young adult age) years [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2020 (9 études épidémiologiques, 10 383 patientes), cette méta-analyse évalue l'association entre l'infertilité et le risque de cancer de l'ovaire

Infertility and ovarian cancer risk: evidence from nine prospective cohort studies

Jiang, Yu-Ting ; Gong, Ting-Ting ; Zhang, Jia-Yu ; Li, Xiu-Qin ; Gao, Song ; Zhao, Yu-Hong ; Wu, Qi-Jun

Epidemiological studies have investigated the relationship between infertility and the risk of ovarian cancer (OC); however, the results have been inconsistent. We therefore conducted the first meta-analysis to update and quantify the aforementioned association on the basis of prospective cohort studies. Studies were identified by searching PubMed, EMBASE, and Web of Science databases up to January 8, 2020. We extracted data from the studies and performed quality assessments. Summary relative [...]

Menée à partir des données du projet "The Cancer Genome Atlas" et de deux études d'association sur le génome entier portant sur 20 871 patients atteints d'un cancer du poumon et sur 15 971 témoins (âge moyen : 64 ans), cette étude identifie 7 polymorphismes à simple nucléotide de gènes impliqués dans la tumorigenèse pulmonaire et pouvant être associés au risque de développer la maladie

Association analysis of driver-gene related genetic variants identified novel lung cancer susceptibility loci with 20,871 lung cancer cases and 15,971 controls

Wang, Yuzhuo ; Gorlova, Olga Y. ; Gorlov, Ivan P. ; Zhu, Meng ; Dai, Juncheng ; Albanes, Demetrius ; Lam, Stephen ; Tardon, Adonina ; Chen, Chu ; Goodman, Gary E. ; Bojesen, Stig E. ; Landi, Maria Teresa ; Johansson, Mattias ; Risch, Angela ; Wichmann, Heunz-Erich ; Bickeböller, Heike ; Christiani, David C. ; Rennert, Gad ; Arnold, Susanne M ; Brennan, Paul ; Field, John K. ; Shete, Sanjay ; Le Marchand, Loic ; Melander, Olle ; Brunnström, Hans ; Liu, Geoffrey ; Hung, Rayjean J. ; Andrew, Angeline S. ; Kiemeney, Lambertus A ; Zienolddiny, Shanbeh ; Grankvist, Kjell ; Johansson, Mikael ; Caporaso, Neil E. ; Woll, Penella J ; Lazarus, Philip ; Schabath, Matthew B. ; Aldrich, Melinda C. ; Stevens, Victoria L. ; Ma, Hongxia ; Jin, Guangfu ; Hu, Zhibin ; Amos, Christopher I. ; Shen, Hongbing

Background: A substantial proportion of cancer driver genes (CDGs) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been investigated. Methods: We selected expression-related single nucleotide polymorphisms (eSNPs) and nonsynonymous variants of lung CDGs, and tested their associations with lung cancer risk in two large-scale genome-wide association studies (20,871 cases and 15,971 controls of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2019 (11 études, 19 083 patients), cette méta-analyse évalue le risque de cancer colorectal chez les personnes présentant une mutation BRCA

Risk of colorectal cancer associated with BRCA1 and/or BRCA2 mutation carriers: systematic review and meta-analysis

Cullinane, C. M. ; Creavin, B. ; O'Connell, E. P. ; Kelly, L. ; O'Sullivan, M. J. ; Corrigan, M. A. ; Redmond, H. P.

Background: Carriers of the BRCA1 and/or BRCA2 mutation incur a lifetime risk of up to 85 per cent for breast cancer, and between 20 and 40 per cent for ovarian cancer. Efforts to estimate the lifetime risk of developing colorectal cancer for BRCA mutation carriers have produced conflicting results. Consequently, there are no formal guidelines regarding the need for bowel screening for individuals with BRCA1 and/or BRCA2 mutations. This systematic review and meta-analysis determined the risk of [...]