Menée en France à partir de données portant sur 263 patients ayant survécu à un cancer (colorectal, sein, col de l’utérus) et sur 688 témoins (âge moyen : 66 ans), cette étude analyse leur degré de fatigue, d'anxiété et leur qualité de vie, 15 ans après le diagnostic de la maladie

Cancer-related fatigue among long-term survivors of breast, cervical, and colorectal cancer: a French registry–based controlled study

François Gernier, Florence Joly, Delphine Klein (et al.)

Background : While several studies have documented fatigue during and after cancer treatment, long-term cancer survivor fatigue is underreported. In this study, we compare fatigue, quality of life (QoL), and anxiety between relapse-free cancer survivors 15 years after diagnosis and healthy controls. Methods : Cancer survivors (CS) were randomly selected from three large population-based cancer registries (Bas-Rhin, Calvados, and Doubs, France). Cancer-free controls were randomly selected from [...]

Menée au Canada à partir de données portant sur 1 310 patients atteints d’un cancer diagnostiqué entre 2016 et 2017, cette étude de cohorte rétrospective analyse leurs symptômes auto-déclarés et leurs besoins en soins de support au moment du diagnostic

Patient-reported symptom burden and supportive care needs at cancer diagnosis: a retrospective cohort study

Colleen A. Cuthbert, Devon J. Boyne, Xu Yuan (et al.)

Purpose : Patient-reported outcomes (PROs) are used to assess patients’ symptoms and supportive care needs. While PROs are increasingly employed in clinical practice, research utilizing these data remains limited. Our goal was to evaluate PROs from a provincial cancer program. Methods : A retrospective, population-based cohort study using administrative health data of patients in Alberta, Canada, diagnosed with cancer between January 1, 2016, and October 23, 2017. Adults who completed PROs [...]

Menée au Royaume-Uni et en Irlande sur la période 2011-2016 à partir de données portant sur 1 027 patients atteints d’un cancer incurable de stade avancé (âge médian : 66 ans), cette étude identifie les facteurs associés à la qualité de vie

Determinants of quality of life in patients with incurable cancer

Louise E. Daly, Ross D. Dolan, Derek G. Power (et al.)

Background : Optimizing quality of life (QoL) remains the central tenet of care in patients with incurable cancer; however, determinants of QoL are not clear. The objective of the current study was to examine which factors influence QoL in patients with incurable cancer. Methods : A multicenter study of adult patients with advanced cancer was conducted in Ireland and the United Kingdom between 2011 and 2016. Data were collected from patients at study entry and included patient demographics, [...]

Menée aux Pays-Bas à partir de données portant sur 261 patients ayant survécu à un cancer colorectal, cette étude longitudinale analyse l’association entre le niveau sérique de vitamine D et la qualité de vie ainsi que la fatigue, pendant les 2 années suivant les traitements

Higher serum vitamin D concentrations are longitudinally associated with better global quality of life and less fatigue in colorectal cancer survivors up to 2 years after treatment

Janna L. Koole, Martijn J.L. Bours, Eline H. van Roekel (et al.)

Background:Vitamin D status may be an important determinant of health-related quality of life of colorectal cancer (CRC) survivors. The current study investigated longitudinal associations between serum 25-hydroxyvitamin D3 (25OHD3) concentrations and quality of life in stage I-III CRC survivors up to 2 years post-treatment. Methods:CRC patients (n=261) were included upon diagnosis. Home visits (including blood sampling) were performed at diagnosis and at 6 weeks, 6 months, 1 and 2 years [...]

Menée aux Etats-Unis par enquête auprès de 415 patientes ayant survécu à un cancer du sein (241 répondantes), cette étude analyse leurs expériences relatives à l’acupuncture pour réduire la sévérité de leurs symptômes

Real-world experiences with acupuncture among breast cancer survivors: a cross-sectional survey study

Jacqueline Zayas, Kathryn J. Ruddy, Janet E. Olson (et al.)

Purpose : The purpose of this study was to evaluate acupuncture use among breast cancer survivors, including perceived symptom improvements and referral patterns. Methods : Breast cancer survivors who had used acupuncture for cancer- or treatment-related symptoms were identified using an ongoing prospective Mayo Clinic Breast Disease Registry (MCBDR). Additionally, Mayo Clinic electronic health records (MCEHR) were queried to identify eligible participants. All received a mailed consent form [...]

Mené aux Etats-Unis sur 38 patientes atteintes d’un cancer du sein de stade II ou III, cet essai randomisé évalue l’efficacité d’une intervention pour prévenir la prise de poids pendant une chimiothérapie néoadjuvante

Feasibility and efficacy of a weight gain prevention intervention for breast cancer patients receiving neoadjuvant chemotherapy: a randomized controlled pilot study

Karen M. Basen-Engquist, Margaret Raber, Cindy L. Carmack (et al.)

Purpose : Weight gain is common among breast cancer patients and may contribute to poorer treatment outcomes. Most programs target breast cancer survivors after the completion of therapy and focus on weight reduction. This study examined the feasibility and preliminary efficacy of an intervention designed to prevent primary weight gain among women receiving neoadjuvant chemotherapy for breast cancer. Methods : Thirty-eight newly diagnosed stage II or III breast cancer patients were randomized [...]

Menée aux Etats-Unis à partir de données portant sur 1 340 patientes atteintes d’un cancer du sein à haut risque de récidive, cette étude analyse l’évolution de la pratique d’une activité physique, avant, pendant et après une chimiothérapie, et analyse l’effet de cette activité physique sur la survie

Physical activity before, during and after chemotherapy for high-risk breast cancer: relationships with survival

Rikki A Cannioto, Alan Hutson, Shruti Dighe (et al.)

Background : Although physical activity has been consistently associated with reduced breast cancer mortality, evidence is largely based upon data collected at one occasion. We examined how pre- and post-diagnosis physical activity was associated with survival outcomes in high-risk breast cancer patients. Methods : Included were 1,340 patients enrolled in the DELCaP Study, a prospective study of lifestyle and prognosis ancillary to a SWOG clinical trial (S0221). Activity before diagnosis, [...]

Mené sur 108 patients atteints d’un cancer de la tête et du cou, cet essai de phase II évalue l’efficacité et la toxicité du dentoxol, utilisé en bain de bouche, pour prévenir et réduire la sévérité d’une mucite buccale induite par la radiothérapie

Efficacy and safety of Dentoxol in the prevention of radiation-induced oral mucositis in head and neck cancer patients (ESDOM): a randomized, multicenter, double-blind, placebo-controlled, phase II trial

Rajesh V. Lalla, Sebastián Solé, Sergio Becerra (et al.)

Purpose : The aim of this study was to assess the efficacy and safety of Dentoxol mouthrinse in reducing the severity of oral mucositis (OM) secondary to radiation therapy (RT) for head and neck cancer. Methods : A randomized, double-blind, placebo-controlled, multicenter phase II clinical trial was conducted. Subjects were asked to use Dentoxol (n?=?55) or control (n?=?53) mouthrinse 5 times/day during RT. Twice a week, OM was assessed clinically using the WHO scale and the Oral Mucositis [...]

Menée à partir des données des registres américains des cancers portant sur 950 377 patients atteints d’un cancer diagnostiqué entre 2004 et 2010 (prostate, ovaire, sein, estomac, pancréas, poumon, foie, œsophage, colorectal), cette étude analyse les disparités ethniques dans le stade de la maladie au moment du diagnostic, dans les traitements reçus et dans la survie

Differences in Stage of Cancer at Diagnosis, Treatment, and Survival by Race and Ethnicity Among Leading Cancer Types

Chenyue Zhang, Chenxing Zhang, Qingliang Wang (et al.)

Importance : Information about stage of cancer at diagnosis, use of therapy, and survival among patients from different racial/ethnic groups with 1 of the most common cancers is lacking. Objective : To assess stage of cancer at diagnosis, use of therapy, overall survival (OS), and cancer-specific survival (CSS) in patients with cancer from different racial/ethnic groups. Design, Setting, and Participants : This cohort study included 950?377 Asian, black, white, and Hispanic patients who were [...]

Menée dans 25 pays à partir de données d’enquête portant sur environ 10 000 patients pédiatriques atteints d’un cancer, cette étude analyse la prévalence et la sévérité d’une infection par le COVID-19

Flash Survey on SARS-CoV-2 Infections in Pediatric Patients on anti-Cancer Treatment

Ondrej Hrusaka, Tomas Kalinaa, Joshua Wolf (et al.)

Introduction : Since the beginning of COVID-19 pandemics, it is known that the severe course of the disease occurs mostly among elderly, whereas it is rare among children and young adults. Comorbidities, in particular diabetes and hypertension, clearly associated with age, besides obesity and smoke are strongly associated with the need of intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Along [...]

Menée à partir des données du registre californien des cancers portant sur 1 062 adolescents et jeunes adultes (âge : 15-39 ans) ayant survécu 3 ans ou plus à une leucémie lymphoblastique aiguë diagnostiquée entre 1995 et 2012, cette étude analyse les facteurs associés à la survenue tardive d’effets indésirables (maladies et dysfonctionnements physiques, second cancer)

Late Effects in Survivors of Adolescent and Young Adult Acute Lymphoblastic Leukemia

Lori Muffly, Frances B Maguire, Qian Li (et al.)

Background : Knowledge regarding late effects (medical conditions and subsequent neoplasms) in survivors of adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) is lacking. Methods : Using the population-based California Cancer Registry (CCR) linked with California hospitalization data, we evaluated late effects in 1,069 AYAs (age 15-39 years) diagnosed with ALL in California between 1995-2012 and surviving a minimum of three years from diagnosis. Results : The estimated 10-year [...]

Menée en Angleterre et au Pays de Galles à partir de données portant sur 3 688 916 hommes décédés d’un cancer de la plèvre ou du poumon (âge : 20-74 ans) sur la période 1979-2019, cette étude analyse la part des décès attribuable à une exposition professionnelle à l’amiante selon la localisation de la tumeur

Relative burden of lung and pleural cancers from exposure to asbestos: a cross-sectional analysis of occupational mortality in England and Wales

Elizabeth Clare Harris, Stefania D'Angelo, Andrew Darnton (et al.)

Objectives : To explore the extent to which asbestos-exposed jobs vary in the ratio of excess mortality from lung cancer to deaths from pleural cancer. Design : Using data on underlying cause of death and last full-time occupation for 3?688?916 deaths among men aged 20–74 years in England and Wales during 1979–2010, we calculated proportional mortality ratios (PMRs), standardised for age and social class, with all occupations combined as reference. For each of 22 asbestos-exposed job groups [...]

Menée aux Etats-Unis à partir de données portant sur 8 330 et 6 942 hommes ayant survécu à un cancer de la prostate non métastatique diagnostiqué entre 1992 et 2013, cette étude analyse l’association entre l’indice de masse corporelle et des changements de poids mesurés après le diagnostic, et la mortalité spécifique et toutes causes confondues

Postdiagnosis Body Mass Index, Weight Change, and Mortality From Prostate Cancer, Cardiovascular Disease, and All Causes Among Survivors of Nonmetastatic Prostate Cancer

Alyssa N. Troeschel, Terryl J. Hartman, Eric J. Jacobs (et al.)

PURPOSE : To investigate the association of postdiagnosis body mass index (BMI) and weight change with prostate cancer–specific mortality (PCSM), cardiovascular disease–related mortality (CVDM), and all-cause mortality among survivors of nonmetastatic prostate cancer. METHODS : Men in the Cancer Prevention Study II Nutrition Cohort diagnosed with nonmetastatic prostate cancer between 1992 and 2013 were followed for mortality through December 2016. Current weight was self-reported on follow-up [...]

Menée aux Etats-Unis à partir de données portant sur 354 patientes atteintes d’un cancer du sein, cette étude rétrospective analyse les facteurs associés au risque de développer un syndrome des cordelettes axillaires après un traitement chirurgical, et analyse son association avec un lymphœdème

Incidence and predictors of axillary web syndrome and its association with lymphedema in women following breast cancer treatment: a retrospective study

Kathryn Ryans, Claire C. Davies, Gizela Gaw (et al.)

Purpose : Axillary web syndrome (AWS) presents as a common postsurgical complication in individuals with breast cancer. Breast cancer–related lymphedema (BCRL) contributes to the shoulder and arm morbidity common in breast cancer survivors and often associated to cancer treatment. A paucity of literature exists evaluating the risk factors for developing AWS and the association between AWS and BCRL. The purposes of this study were (1) to identify risk factors for AWS in individuals with breast [...]

Menée aux Etats-Unis à partir de données portant sur 190 patients atteints d’un cancer de la tête et du cou, cette étude analyse l’association entre la durée quotidienne d’exposition à la radiothérapie et la sévérité d’une mucite buccale

Daily Time of Radiation Treatment is Associated with Subsequent Oral Mucositis Severity during Radiotherapy in Head and Neck Cancer Patients

Fangyi Gu, Mark K. Farrugia, William D. Duncan (et al.)

Background: Limited treatment options are available for oral mucositis, a common, debilitating complication of cancer therapy. We examined the association between daily delivery time of radiotherapy and the severity of oral mucositis in patients with head and neck cancer. Methods: We used electronic medical records of 190 patients with head and neck squamous cell carcinoma who completed radiotherapy, with or without concurrent chemotherapy, at Roswell Park Comprehensive Cancer Center (Buffalo, [...]

Menée aux Etats-Unis par entretiens auprès de 123 patients ayant survécu à un cancer des voies aérodigestives, cette étude analyse, à 6, 12 et 18 mois après le diagnostic, l’évolution de l’association entre la présence d’une douleur chronique et des symptômes de stress post-traumatique

Post-Traumatic Stress Disorder Symptoms from Multiple Stressors Predict Chronic Pain in Cancer Survivors

Zachary S. Sager, Jennifer S. Wachen, Aanand D. Naik (et al.)

Background: Despite the association between chronic pain and post-traumatic stress disorder (PTSD), little is known about the longitudinal course of pain and PTSD during cancer treatment. Objectives: We examined the prevalence of PTSD and chronic pain at three time periods in veterans with a diagnosis of cancer, and the relationship between the experience of pain and PTSD. Methods: Participants (N?=?123) with oral-digestive cancers were recruited from the Veterans Healthcare System (age [...]

Menée aux Pays-Bas auprès de 192 patients ayant reçu un traitement systémique pour un cancer (hors cancer du système nerveux central) et auprès de 192 témoins, cette étude analyse l’efficacité d’un test neuropsychologique pour évaluer les dysfonctionnements cognitifs liés au cancer et à ses traitements

Computational Modeling of Neuropsychological Test Performance to Disentangle Impaired Cognitive Processes in Cancer Patients

Joost A Agelink van Rentergem, Ivar E Vermeulen, Philippe R Lee Meeuw Kjoe (et al.)

There is a need to better identify impaired cognitive processes to increase our understanding of cognitive dysfunction caused by cancer and cancer treatment, and improve interventions. The Trail Making Test is frequently used for evaluating information processing speed (part A) and executive function (part B), but interpretation of its outcomes is challenging because performance depends on many cognitive processes. To disentangle processes, we collected high-resolution data from 192 non-central [...]

Menée aux Pays-Bas par questionnaire auprès de 1 066 participants âgés de 55 à 75 ans, cette étude de cohorte prospective analyse leur détresse psychologique et leur qualité de vie après la notification d’un résultat positif au test de dépistage du cancer colorectal (test de recherche de sang occulte dans les selles puis coloscopie)

Psychological distress and quality of life following positive fecal occult blood testing in colorectal cancer screening

Nina C.A. Vermeer, Maxime J.M. van der Valk, Heleen S. Snijders (et al.)

Objective : This study aimed to assess psychological functioning, quality of life, and regret about screening after a positive FIT and subsequent colonoscopy, and to evaluate changes over time. Methods :This is a prospective cohort study. Individuals aged 55?75 with a positive Fecal Immunochemical Test (FIT) that were referred for colonoscopy between July 2017 and November 2018, were invited to complete questionnaires related to psychological distress and health?related quality of life at three [...]

Cet article commente les mesures prises en Chine pour prendre en charge les patients atteints d’un cancer pendant la période de propagation du COVID-19

Active and Effective Measures for the Care of Patients With Cancer During the COVID-19 Spread in China

Zhijie Wang, Jie Wang, Jie He

Recently, an outbreak of the highly infectious novel coronavirus disease 2019 (COVID-19) has swept Wuhan, China, with 80?303 confirmed diagnosed cases in China as of March 3, 2020.1 Considering its high risk of person-to-person transmission, hospitals, especially in China, are the typical congregating places that will bear the brunt of this infectious disease. To reduce or avoid cross infection of COVID-19, many hospitals have started taking actions to limit the number of outpatient visits and [...]

Menée aux Etats-Unis, cette étude analyse les coûts associés à l’utilisation des immunothérapies à base de lymphocytes CAR-T chez des patients atteints d’un lymphome à grandes cellules B réfractaire ou récidivant, selon le lieu de prise en charge

Economic Evaluation of Chimeric Antigen Receptor T-Cell Therapy by Site of Care Among Patients With Relapsed or Refractory Large B-Cell Lymphoma

Gary H. Lyman, Andy Nguyen, Sophie Snyder (et al.)

Importance : Chimeric antigen receptor (CAR) T-cell therapies are currently administered at a limited number of cancer centers and are primarily delivered in an inpatient setting. However, variations in total costs associated with these therapies remain unknown. Objective : To estimate the economic differences in the administration of CAR T-cell therapy by the site of care and the incidence of key adverse events. Design, Setting, and Participants : A decision-tree model was designed to capture [...]

A partir d’une revue de la littérature publiée entre 2005 et 2019 (20 essais randomisés, 1 669 patients), cette méta-analyse évalue l’intérêt, du point de vue de l’amélioration de la qualité de vie, de l’ajout des médecines traditionnelles chinoises à une chimiothérapie, chez des patients atteints d’un cancer du poumon non à petites cellules

Efficacy of traditional Chinese Medicine combined with chemotherapy in patients with non-small cell lung cancer (NSCLC): a meta-analysis of randomized clinical trials

Jiani Yang, Xingmei Zhu, Panpan Yuan (et al.)

Background : This meta-analysis systematically evaluated the efficacy of Traditional Chinese Medicine (TCM) combined with chemotherapy and provided evidence-based evidence for the treatment of non-small cell lung cancer. Methods : Biomedical databases including China National Knowledge Infrastructure (CNKI) database, Wanfang Database, PubMed, and Cochrane Library were searched from January 2005 to October 2019 for the clinical literature on Chinese medicine for treating non-small cell lung [...]

Cet article présente l’outil de télémédecine (application web et plateforme téléphonique) utilisé par l’Institut Gustave Roussy pour améliorer le suivi et la prise en charge des patients atteints d’un cancer pendant la période de crise liée au COVID-19

PRO platform, a useful tool to improve monitoring and effective management of Covid-19 cancer patients

Florian Scotté, Etienne Minvielle, Olivier Mir (et al.)

A central strategy for health care surge control would be to provide remote effective monitoring of Covid-19 patients and their follow-up. Telemedicine allows patients not only to be carefully screened, but also enabling a patient-centered system as well as being conducive to self-quarantine. Also patients, clinicians, and the community are protected from exposure .Patients with cancer during or after treatment, have an increased risk of complication and death related to Covid-19 contagion. In [...]

A partir d'une revue systématique de la littérature (17 articles), cette méta-analyse compare la performance, du point de vue notamment de la sensibilité, de la spécificité et de la précision, d'algorithmes utilisant des données administratives pour estimer au niveau de la population le nombre de cancers du sein ayant récidivé

A Systematic Review of Estimating Breast Cancer Recurrence at the Population-Level with Administrative Data

Izci, Hava ; Tambuyzer, Tim ; Tuand, Krizia ; Depoorter, Victoria ; Laenen, Annouschka ; Wildiers, Hans ; Vergote, Ignace ; van Eycken, Liesbet ; De Schutter, Harlinde ; Verdoodt, Freija ; Neven, Patrick

Background : Exact numbers of breast cancer (BC) recurrences are currently unknown at the population-level, since they are challenging to actively collect. Previously, real-world data such as administrative claims have been used within expert- or data-driven (machine learning) algorithms for estimating cancer recurrence. We present the first systematic review and meta-analysis of publications estimating BC recurrence at the population-level using algorithms based on administrative data. Methods [...]