Menée aux Etats-Unis à partir de données portant sur 10 012 patients ayant survécu à un cancer diagnostiqué pendant l’enfance sur la période 1970-1986 (âge médian : 31 ans ; durée médiane depuis le diagnostic : 23 ans) et sur 3 173 témoins, cette étude longitudinale évalue les facteurs associés à l’intensité de la douleur et à son impact sur les activités de la vie quotidienne

Longitudinal pain and pain interference in long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Cynthia W. Karlson, Nicole M. Alberts, Wei Liu (et al.)

Background : The objective of this study was to characterize the prevalence and risk of pain, pain interference, and recurrent pain in adult survivors of childhood cancer in comparison with siblings. Methods : This study analyzed longitudinal data from survivors (n = 10,012; 48.7% female; median age, 31 years [range, 17?57 years]; median time since diagnosis, 23 years) and siblings (n = 3173) from the Childhood Cancer Survivor Study. Survivors were diagnosed between 1970 and 1986 at 1 of 26 [...]

Menée au Canada par entretiens auprès de 50 enfants atteints d’un cancer ou ayant reçu une greffe de cellules souches hématopoïétiques (âge : 4-10 ans), cette étude qualitative analyse les facteurs associés à des changements d’appétit

Changes in hunger among pediatric patients with cancer and hematopoietic stem cell transplantation recipients

Robyn Loves, Erin Plenert, Vivian Tomlinson (et al.)

Purpose : Change in hunger is a common and bothersome symptom among pediatric patients receiving cancer treatments. Objectives were to describe how children and adolescents receiving cancer treatments experience changes in hunger, factors associated with both increases and decreases in hunger, and coping strategies used by these patients. Methods : We enrolled children and adolescents 4–18 years of age with cancer or hematopoietic stem cell transplantation (HSCT) recipients who were actively [...]

Menée à partir des données des registres américains des cancers et de la base Medicare sur la période 2007-2014 et portant sur 1 486 patients ayant survécu à un cancer et sur 3 682 témoins, cette étude analyse l’utilisation d’opioïdes pour soulager la douleur induite par un traitement chirurgical non lié au cancer

Cancer survivorship and its association with perioperative opioid use for minor non-cancer surgery

Samantha Eiffert, Andrea L. Nicol, Edward F. Ellerbeck (et al.)

Purpose : Reducing high-risk prescription opioid use after surgery has become a key strategy in mitigating the opioid crisis. Yet, despite their vulnerabilities, we know little about how cancer survivors use opioids for non-cancer perioperative pain compared to those with no history of cancer. The purpose was to examine the association of cancer survivorship with the likelihood of receiving perioperative opioid therapy for non-cancer minor surgery. Methods : Using 2007–2014 SEER-Medicare data [...]

Menée en France par enquête auprès de 92 patientes ayant survécu à un cancer gynécologique diagnostiqué entre 2006 et 2013 (col de l’utérus, endomètre, ovaire), cette étude analyse leurs difficultés socioéconomiques et professionnelles (durée moyenne de suivi après le diagnostic : 6 ans)

Socio-economic and occupational outcomes of long-term survivors of gynaecological cancer: A French population-based study

Ariane Mamguem Kamga, Agnès Dumas, Florence Joly (et al.)

Objective : To describe socio?economic and professional outcomes in long?term survivors of cervical, endometrial or ovarian cancer, including return to work and problems related to obtaining loans and insurance. Methods : Women with cervical, endometrial or ovarian cancers diagnosed from 2006 to 2013 were selected through the French gynaecological cancer registry of Côte d’Or, in a cross?sectional survey. Using a questionnaire established with the help of sociologists and psychologists, social [...]

Menée à partir des données des registres américains des cancers portant sur des patients âgés de 50 à 79 ans atteints d’un cancer diagnostiqué sur la période 2006-2015 (17 types de localisations cancéreuses), cette étude présente une estimation de la réduction du nombre de décès par cancer si la maladie était détectée avant son stade IV de développement (stade métastatique)

Projected Reductions in Absolute Cancer–Related Deaths from Diagnosing Cancers Before Metastasis, 2006–2015

Christina A. Clarke, Earl Hubbell, Allison W. Kurian

Background: New technologies are being developed for early detection of multiple types of cancer simultaneously. To quantify the potential benefit, we estimated reductions in absolute cancer–related deaths that could occur if cancers diagnosed after metastasis (stage IV) were instead diagnosed at earlier stages. Methods: We obtained stage-specific incidence and survival data from the Surveillance, Epidemiology, and End Results Program for 17 cancer types for all persons diagnosed ages 50 to 79 [...]

Menée en Chine, cette étude rétrospective analyse les caractéristiques de 28 patients atteints d’un cancer et infectés par le coronavirus (COVID-19)

Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China

L.Zhang, F.Zhu, L.Xie (et al.)

Background : Cancer patients are regarded as a highly vulnerable group in the current Coronavirus Disease 2019 (COVID-19) pandemic. To date, the clinical characteristics of COVID-19-infected cancer patients are largely unknown. Patients and methods : In this retrospective cohort study, we included cancer patients with laboratory confirmed COVID-19 from three designated hospitals in Wuhan, China. The clinical data were collected from medical records from Jan 13, 2020, to Feb 26, 2020. Univariate [...]

A partir d’une revue systématique de la littérature publiée jusqu’en juin 2019 (16 études, 1 224 patients), cette étude analyse les fonctions physiques chez des patients atteints d’un cancer du pancréas ou du foie ayant été réséqué

Physical function in patients with resectable cancer of the pancreas and liver–a systematic review

Linda O’Neill, Sophie Reynolds, Gráinne Sheill (et al.)

Purpose : Surgery is the only potentially curative treatment for pancreatic and liver cancer. However, even in high-volume centres, surgical resection is associated with significant morbidity with resultant physical decline. This systematic review explored physical function and its’ implications in the management of resectable cancer of the pancreas and liver. Methods : EMBASE, Medline OVID, CINAHL, Cochrane Library and Web of Science were searched up to June 2019 using a predefined search [...]

Menée dans l’Etat du Massachusetts sur la période 2001-2015, cette étude analyse les disparités ethniques et socioéconomiques dans le stade au diagnostic de la maladie chez des patients atteints de divers types de cancer (sein, col de l’utérus, colorectal, poumon)

Cancer Stage at Diagnosis, Historical Redlining, and Current Neighborhood Characteristics: Breast, Cervical, Lung, and Colorectal Cancer, Massachusetts, 2001-2015

Nancy Krieger, Emily Wright, Jarvis T Chen (et al.)

In the 1930s, the federal Home Owners’ Loan Corporation (HOLC) maps nationalized racial residential segregation via “redlining,” whereby the color red designated areas with black, foreign-born, or low-income residents, which were deemed unsuitable for mortgage lending. We used the recently digitized HOLC redlining maps for 28 municipalities in Massachusetts to analyze Massachusetts Cancer Registry data for late stage at diagnosis for cervical, breast, lung, and colorectal cancer (2001-2015). [...]

Menée aux Etats-Unis à partir des données d’une enquête menée sur la période 1988-1994 auprès de 14 498 participants, cette étude analyse l’association entre une infection par le cytomégalovirus et la mortalité par cancer

Cytomegalovirus and cancer-related mortality in the national health and nutritional examination survey

Olasunmbo O. Okedele, Heather H. Nelson, Mosun L. Oyenuga (et al)

Purpose : Cytomegalovirus (HCMV) is a common viral infection that shapes lifelong immunity. A history of infection with HCMV has been associated with many chronic diseases, including cancer. In addition, prospective cohort studies have established that HCMV is associated with all-cause mortality. However, there are limited data regarding HCMV and cancer mortality. Methods : Data were obtained from the National Health and Nutrition Examination Survey (NHANES) III study (1988–1994): subjects aged [...]

Menée aux Etats-Unis à partir de données portant sur 57 843 patientes atteintes d’un cancer du sein diagnostiqué entre 2007 et 2017 (âge : supérieur ou égal à 45 ans ; durée moyenne de suivi : 5,5 ans), cette étude de cohorte rétrospective analyse l’association entre une hormonothérapie (tamoxifène et inhibiteurs de l’aromatase, notamment l’exémestane) et le risque de maladies neurodégénératives (Alzheimer, démence)

Association Between Hormone-Modulating Breast Cancer Therapies and Incidence of Neurodegenerative Outcomes for Women With Breast Cancer

Gregory L. Branigan, Maira Soto, Leigh Neumayer (et al.)

Importance : The association between exposure to hormone-modulating therapy (HMT) as breast cancer treatment and neurodegenerative disease (NDD) is unclear. Objective : To determine whether HMT exposure is associated with the risk of NDD in women with breast cancer. Design, Setting, and Participants : This retrospective cohort study used the Humana claims data set from January 1, 2007, to March 31, 2017. The Humana data set contains claims from private-payer and Medicare insurance data sets [...]

Menée au Royaume-Uni à partir de données portant sur 862 patientes âgées de moins de 40 ans et atteintes d’un cancer du sein de stade métastatique, cette étude de cohorte compare, chez celles présentant un cancer métastatique de novo et chez celles ayant développé des métastases ultérieurement, les caractéristiques associées à la survie globale et à la survie sans récidive à distance (durée médiane de suivi : 11 ans)

Survival and disease characteristics of de novo versus recurrent metastatic breast cancer in a cohort of young patients

Hayley S. McKenzie, Tom Maishman, Peter Simmonds (et al.)

Background : It is not clear how the pathology, presentation and outcome for patients who present with de novo metastatic breast cancer (dnMBC) compare with those who later develop distant metastases. DnMBC is uncommon in younger patients. We describe these differences within a cohort of young patients in the United Kingdom. Methods : Women aged 40 years or younger with a first invasive breast cancer were recruited to the prospective POSH national cohort study. Baseline clinicopathological data [...]

Menée aux Etats-Unis à partir de données portant sur 151 patientes atteintes d’un cancer du sein et sur 2 163 témoins (âge moyen : 46,4 ans), cette étude analyse les facteurs associés à l’évolution de la pratique d’une activité physique, avant et après le diagnostic de la maladie

The impact of breast cancer on physical activity from midlife to early older adulthood and predictors of change post-diagnosis

Kelley Pettee Gabriel, Barbara Sternfeld, Alicia B. Colvin (et al.)

Purpose : To examine physical activity (PA) patterns from pre- to post-diagnosis, and compare these changes to women without breast cancer. To determine pre-diagnosis predictors of PA change, post-diagnosis, in breast cancer survivors (BCS). Methods : Data were from 2314 Study of Women’s Health Across the Nation (SWAN) participants, average age of 46.4?±?2.7 years at baseline (1996–1997). In Pink SWAN, 151 women who reported an incident breast cancer diagnosis over 20 years were classified as [...]

Menée aux Etats-Unis auprès de 185 parents d’enfants âgés de moins de 12 ans, atteints d’un cancer et ayant reçu une greffe de cellules souches hématopoïétiques, cette étude longitudinale analyse l’intérêt d’un outil permettant aux parents de mesurer leur sentiment d’auto-efficacité et de réduire la détresse psychologique de la famille

Parental Efficacy and Control Questionnaire in Hematopoietic Stem Cell Transplant: Preliminary Validation

Ahna L H Pai, Marie L Chardon, Constance A Mara (et al.)

Objective : Develop and evaluate the preliminary validity of a self-report measure of parents’ treatment-related efficacy and control, Parental Efficacy and Control Questionnaire-Hematopoietic Stem Cell Transplant (PECQ-HCT), in a pediatric HCT sample. Methods : Participants included 185 parents of children (?12?years old) receiving HCT participating in a larger, longitudinal study. Parents completed the PECQ-HCT as well as measures of social problem-solving skills, collective family efficacy, [...]

A partir d’une revue systématique de la littérature publiée depuis 2016 (23 études), cette étude analyse les interactions entre les troubles physiques et psychologiques au sein de dyades constituées du patient atteint d'un cancer et d'un proche aidant (principalement le conjoint)

Interdependence of Physical and Psychological Morbidity Among Patients with Cancer and Family Caregivers: Review of the Literature

Brennan P. Streck, Diane W. Wardell, Geri LoBiondo?Wood (et al.)

Objective : Caregivers for patients with cancer have an integral role in maintaining patients' health. Although patients and caregivers experience the impact of cancer individually, studies suggest their health is interdependent. The objective of this review was to synthesize the literature on interdependent physical and psychological morbidity in patient?caregiver dyads published since 2016. Methods : A search of PubMed, CINAHL, Embase, and PsycInfo databases was performed using Cooper's [...]

Cet article fait le point sur les enjeux associés à la structuration des dossiers médicaux électroniques et à leur utilisation dans un système de santé

Status Update on Data Required to Build a Learning Health System

Monica M. Bertagnolli, Brian Anderson, Kelly Norsworthy (et al.)

Wide adoption of electronic health records (EHRs) has raised the expectation that data obtained during routine clinical care, termed “real-world” data, will be accumulated across health care systems and analyzed on a large scale to produce improvements in patient outcomes and the use of health care resources. To facilitate a learning health system, EHRs must contain clinically meaningful structured data elements that can be readily exchanged, and the data must be of adequate quality to draw [...]

Cet article français commente les recommandations du Haut Conseil de la Santé Publique pour protéger les patients atteints d’un cancer d’une infection par le coronavirus tout en maintenant la possibilité des traitements anticancéreux

The official French guidelines to protect patients with cancer against SARS-CoV-2 infection

Benoit You, Alain Ravaud, Anne Canivet (et al.)

On request of the French Health Ministry, the French High Council for Public health (Haut Conseil de Santé Publique [HCSP]) entrusted a representative group of French medical oncologists and radiation oncologists, working across academic and private practice, with the task of preparing guidelines to protect patients with cancer against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, while maintaining the possibility of cancer treatment. After finalisation of the [...]