A partir d'une revue de la littérature (64 articles), cette méta-analyse décrit la qualité de vie de patients ayant survécu 2 ans ou plus à un cancer

Quality of life in “chronic” cancer survivors: a meta-analysis

Firkins, Jenny ; Hansen, Lissi ; Driessnack, Martha ; Dieckmann, Nathan

Purpose : Cancer survivors are now living longer giving rise to a new concept—chronic cancer as survivors continue to face long-term consequences of cancer and its treatment. For these survivors, QOL becomes a vital consideration in understanding their survivorship and the long-term impact of cancer and its treatment. The primary aim of this review is to describe QOL in cancer survivors two or more years from diagnosis. Methods : A meta-analysis was completed of relevant studies assessing QOL [...]

Cette étude présente les recommandations européennes pour la détection et la prise en charge de la fatigue chez les patients atteints d'un cancer

Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment

Fabi, A. ; Bhargava, R. ; Fatigoni, S. ; Guglielmo, M. ; Horneber, M. ; Roila, F. ; Weis, J. ; Jordan, K. ; Ripamonti, C. I.

This updated ESMO Clinical Practice Guideline provides key recommendations on the management of cancer-related fatigue. Authorship includes a multidisciplinary group of experts from different institutions and countries in Europe and abroad. Key treatment recommendations are provided including levels of evidence and grades of recommendation where applicable.

A partir d'une revue systématique de la littérature publiée entre 2004 et 2019 (59 études), cette étude analyse le risque et la présence de déficiences cognitives induites par la chimiothérapie chez des patients atteints d'un cancer autre qu'un cancer du système nerveux central

Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy

Cerulla Torrente, Noemí ; Navarro Pastor, José-Blas ; de la Osa Chaparro, Nuria

Purpose : The aim of this review is to provide an updated overview of chemotherapy-related cognitive impairment (CRCI) in patients with cancer outside central nervous system (CNS), its incidence and prevalence, the cognitive pattern in neuropsychological studies, neuroimaging findings, and the relationship between chemobrain and aging. Methodological limitations of studies are also discussed. Methods : This review was guided by the PRISMA statement. The MEDLINE and Scopus databases were [...]

Menée au Canada à partir de données portant sur 630 patients atteints d'un cancer de la prostate, cette étude rétrospective analyse l'association entre une activité physique auto-déclarée, le bien-être psychique et la qualité de vie pendant la période de surveillance active

Associations between self-reported physical activity, quality of life and emotional well-being in men with prostate cancer on active surveillance

Papadopoulos, Efthymios ; Alibhai, Shabbir M.H ; Doré, Isabelle ; Matthew, Andrew G. ; Tomlinson, George A. ; Nesbitt, Michael ; Finelli, Antonio ; Trachtenberg, John ; Mina, Daniel Santa

Objective : The relationship between physical activity (PA) and quality of life (QOL) relative to active treatment for prostate cancer (PCa) has been well-studied; however, little is known about this relationship during active surveillance (AS). Moreover, whether PA is associated with better emotional well-being (EWB) in men with low-risk PCa requires further investigation. Accordingly, we examined the association between self-reported PA and the average change in QOL and EWB over time during [...]

Menée aux Etats-Unis à partir de données portant sur 397 patientes âgées de 60 à 98 ans et ayant survécu à un cancer du sein, cette étude analyse l'association entre des déficiences cognitives, auto-déclarées et mesurées objectivement avant un traitement systémique, et leur santé physique et psychosociale, 12 et 24 mois après les traitements

Cognitive function prior to systemic therapy and subsequent well-being in older breast cancer survivors: longitudinal findings from the Thinking and Living with Cancer Study

Kobayashi, Lindsay C. ; Cohen, Harvey Jay ; Zhai, Wanting ; Zhou, Xingtao ; Small, Brent J. ; Luta, George ; Hurria, Arti ; Carroll, Judith ; Tometich, Danielle ; McDonald, Brenna C. ; Graham, Deena ; Jim, Heather S.L. ; Jacobsen, Paul ; Root, James C. ; Saykin, Andrew J. ; Ahles, Tim A. ; Mandelblatt, Jeanne

Background : To investigate the relationships between self-reported and objectively measured cognitive function prior to systemic therapy and subsequent well-being outcomes over 24 months in older breast cancer survivors. Methods : Data were from 397 women aged 60-98 diagnosed with non-metastatic breast cancer in the Thinking and Living with Cancer Study recruited from 2010-2016. Cognitive function was measured at baseline (following surgery, prior to systemic therapy) using neuropsychological [...]

Menée aux Etats-Unis à partir de données portant sur 11 337 patients ayant survécu à un cancer pendant l'enfance (âge médian au diagnostic : 7 ans) et sur 2 146 témoins, cette étude de cohorte analyse les facteurs associés à l'adhésion aux recommandations de surveillance des effets indésirables tardifs causés par les anticancéreux reçus (risque de second cancer, dysfonctions cardiaques)

Adherence to Surveillance for Second Malignant Neoplasms and Cardiac Dysfunction in Childhood Cancer Survivors: A Childhood Cancer Survivor Study

Adam P. Yan ; Yan Chen ; Tara O. Henderson ; Kevin C. Oeffinger ; Melissa M. Hudson ; Todd M. Gibson ; Joseph P. Neglia ; Wendy M. Leisenring ; Kirsten K. Ness ; Jennifer S. Ford ; Leslie L. Robison ; Gregory T. Armstrong ; Yutaka Yasui ; Paul C. Nathan

PURPOSE : To evaluate childhood cancer survivors’ adherence to surveillance protocols for late effects of treatment and to determine the factors affecting adherence. METHODS : Between 2014 and 2016, 11,337 survivors and 2,146 siblings in the Childhood Cancer Survivor Study completed a survey ascertaining adherence to Children’s Oncology Group (COG) guidelines for survivors at high risk for second malignant neoplasms or cardiac dysfunction and to the American Cancer Society (ACS) cancer [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2019 (29 articles, 14 207 patients), cette méta-analyse évalue les facteurs associés au maintien de l'emploi 2 à 14 ans après le diagnostic chez des patients ayant survécu à un cancer

Long-term work retention after treatment for cancer: a systematic review and meta-analysis

de Boer, Angela G. E. M. ; Torp, Steffen ; Popa, Adela ; Horsboel, Trine ; Zadnik, Vesna ; Rottenberg, Yakir ; Bárdi, Edit ; Bültmann, Ute ; Sharp, Linda

Purpose : Almost half of people diagnosed with cancer are working age. Survivors have increased risk of unemployment, but little is known about long-term work retention. This systematic review and meta-analysis assessed work retention and associated factors in long-term cancer survivors. Methods : We searched Medline/Pubmed, Embase, PsychINFO, and CINAHL for studies published 01/01/2000–08/01/2019 reporting work retention in adult cancer survivors ≥ 2 years post-diagnosis. Survivors had to be [...]

Menée à partir de données portant sur 142 patients atteints d'un cancer du poumon non à petites cellules et recevant un traitement de première ou de deuxième ligne par inhibiteurs de points de contrôle immunitaire, cette étude analyse l'effet d'une sarcopénie ou d'une cachexie, mesurées avant le début de l'immunothérapie, sur le taux de contrôle de la maladie, la survie sans progression et la survie globale

Cachexia - sarcopenia as a determinant of disease control rate and survival in non-small lung cancer patients receiving immune-checkpoint inhibitors

Roch, Benoît ; Coffy, Amandine ; Jean-Baptiste, Sandy ; Palaysi, Estelle ; Daures, Jean-Pierre ; Pujol, Jean-Louis ; Bommart, Sébastien

Purpose : The metabolic changes associated with cachexia – sarcopenia syndrome might down-regulate antitumor immunity. We hypothesized that this syndrome reduces efficiency of immune checkpoint inhibitors (ICPI) in non-small cell lung cancer (NSCLC). Methods : The records of 142 consecutive NSCLC patients receiving first- or second-line anti-Programmed cell death protein 1) ICPI were reviewed. Response evaluation according to Response Evaluation Criteria in Solid Tumors 1.1 was performed at the [...]

Menée en Angleterre à partir de données portant sur 56 134 patients âgés de 20 à 49 ans et atteints d'un cancer colorectal diagnostiqué entre 1974 et 2015, cette étude analyse les facteurs démographiques associés à l'évolution de l'incidence de la maladie

Demographic trends in the incidence of young-onset colorectal cancer: a population-based study

Chambers, A. C. ; Dixon, S. W. ; White, P. ; Williams, A. C. ; Thomas, M. G. ; Messenger, D. E.

Background : Evidence is emerging that the incidence of colorectal cancer is increasing in young adults, but the descriptive epidemiology required to better understand these trends is currently lacking. Methods : A population-based cohort study was carried out including all adults aged 20–49 years diagnosed with colorectal cancer in England between 1974 and 2015. Data were extracted from the National Cancer Registration and Analysis Service database using ICD-9/10 codes for colorectal cancer. [...]

Menée aux Etats-Unis à partir de données portant sur 1 363 patientes atteintes d'un cancer du sein diagnostiqué entre 1996 et 1997 et sur 1 358 témoins, cette étude analyse l'association entre un diabète et la mortalité toutes causes confondues ou la mortalité par maladie cardiovasculaire

Diabetes and cardiovascular disease mortality among a population-based cohort of women with and without breast cancer

Rodriguez, Luis A. ; Bradshaw, Patrick T. ; Parada, Humberto ; Khankari, Nikhil K. ; Wang, Tengteng ; Cleveland, Rebecca J. ; Teitelbaum, Susan L. ; Neugut, Alfred I. ; Gammon, Marilie D.

Purpose : We investigated whether the relationship between diabetes and all-cause and CVD-related mortality differed between women with and without breast cancer among a cohort drawn from the same source population. Methods : We interviewed 1,363 women newly diagnosed with breast cancer in 1996–1997, and 1,358 age-matched women without breast cancer, to assess history of physician-diagnosed diabetes. All-cause (n = 631) and CVD-specific mortality (n = 234) was determined by the National Death [...]

Menée à partir des données des registres américains des cancers portant sur 50 148 patients atteints d'un cancer et présentant des métastatases cérébrales diagnostiquées entre 2005 et 2016 (âge : au moins 66 ans), cette étude analyse les facteurs associés à l'utilisation, en fin de vie, de structures d'accueil dédiées

Hospice utilization in elderly patients with brain metastases

Mehanna, Elie K ; Catalano, Paul J ; Cagney, Daniel N ; Haas-Kogan, Daphne A ; Alexander, Brian M ; Tulsky, James A ; Aizer, Ayal A

Brain metastases are associated with considerable morbidity and mortality. Integration of hospice at the end of life offers patients symptom relief and improves quality of life, particularly for elderly patients who are less able to tolerate brain-directed therapy. Population-level investigations of hospice utilization among elderly patients with brain metastases are limited. Using the Surveillance, Epidemiology and End Results (SEER)-Medicare database for primary cancer sites that commonly [...]

Menée aux Etats-Unis sur la période 2000-2016 à partir de données de registres portant sur des patients atteints d'un carcinome papillaire de la thyroïde, cette étude analyse l'incidence, la prévalence et les caractéristiques clinicopathologiques de sous-types aggressifs de la maladie, puis examine la survie

Incidence and Mortality Risk Spectrum Across Aggressive Variants of Papillary Thyroid Carcinoma

Ho, Allen S. ; Luu, Michael ; Barrios, Laurel ; Chen, Irene ; Melany, Michelle ; Ali, Nabilah ; Patio, Chrysanta ; Chen, Yufei ; Bose, Shikha ; Fan, Xuemo ; Mallen-St. Clair, Jon ; Braunstein, Glenn D. ; Sacks, Wendy L. ; Zumsteg, Zachary S.

Importance : While well-differentiated papillary thyroid carcinoma (WDPTC) outcomes have been well characterized, the prognostic implications of more aggressive variants are far less defined. The rarity of these subtypes has led to their consolidation as intermediate risk for what are in fact likely heterogeneous diseases. Objective : To analyze incidence, clinicopathologic characteristics, and outcomes for aggressive variants of papillary thyroid carcinoma (PTC). Design, Setting, and [...]

Menée aux Etats-Unis à partir de données portant sur 100 adolescents et jeunes adultes atteints d'un cancer primitif (âge : 15-39 ans ; 88 % atteints d'une tumeur hématologique), cette étude analyse les facteurs associés à leur utilisation de substances addictives (consommation d'alcool, de cannabis, de tabac) puis évalue l'effet de cette utilisation sur leur santé physique et psychique (dépression, anxiété, qualité du sommeil, activité physique)

Substance Use Behaviors in Adolescent and Young Adult Cancer Patients: Associations with Mental and Physical Health

Asvat, Yasmin ; King, Andrea C. ; Smith, Lia J. ; Lin, Xiaolei ; Hedeker, Donald ; Henderson, Tara O.

OBJECTIVE : Cancer diagnosis in adolescents and young adults (AYA) coincides with the developmental initiation of substance use and emergence of affective disturbance. We examined substance use behaviors and risk-stratified associations with mental and physical health, as well as objective indicators of tobacco and cannabis use and concordance with self-report and medical records. METHODS : AYAs were 15-39 years at cancer diagnosis and ≥ 18 years and ≥ 6 months post-diagnosis at study [...]

Menée aux Etats-Unis à partir de données portant sur 263 patients atteints d'un cancer de la prostate, cette étude transversale analyse l'association entre leur sentiment d'incertitude vis-à-vis de la maladie, leur façon de faire face à la maladie et leur qualité de vie

Illness Uncertainty, Coping, and Quality of Life among Patients with Prostate Cancer

Guan, Ting ; Santacroce, Sheila Judge ; Chen, Ding-Geng ; Song, Lixin

Objective : Illness uncertainty is a significant source of psychological distress that affects cancer patients' quality of life (QOL). Mishel's Uncertainty in Illness Theory (UIT) proposes that illness uncertainty influences an individual's use of coping strategies, and directly and indirectly influences their QOL. This study tested the relationships depicted in the adapted UIT in cancer patients. Methods : This cross‐sectional study is a secondary analysis of the baseline data from a [...]