Ambient Ultraviolet Radiation and Sebaceous Carcinoma Incidence in the United States, 2000-2016

Menée aux Etats-Unis à l'aide de données 2000-2016 des registres des cancers portant sur 3 505 personnes atteintes d'un carcinome épidermoïde cutané, cette étude analyse l'association entre le rayonnement ultraviolet ambiant et le risque de développer la maladie

Résumé en anglais

Sebaceous carcinoma (SC) is an aggressive skin tumor. While ultraviolet radiation (UVR) is an important risk factor for some skin cancer types, no population-level study has evaluated for an association between UVR and SC risk. Herein, we examined satellite-based ambient UVR in relation to SC incidence using Surveillance, Epidemiology, and End Results 18 cancer registry data (2000-2016). There were 3,503 microscopically confirmed cases of SC diagnosed during the study period. For non-Hispanic whites, there was an association between increasing ambient UVR and SC risk (incidence rate ratio, IRR[per UVR quartile]=1.15; 95% CI, 1.11 to 1.19; two-sided P<0.001) including among individuals with and without putative Muir-Torre syndrome (MTS). In contrast, there was no association between ambient UVR and SC risk for other race/ethnicities. Our findings support a role for UVR in SC tumorigenesis, which suggests that photoprotection may reduce SC risk, particularly for high-risk populations (eg. MTS).