Menée aux Etats-Unis à partir de données portant sur 232 patients atteints d'un cancer, cette étude rétrospective évalue l'efficacité, du point de vue de la sévérité de la douleur liée à la maladie, du cannabis thérapeutique

The Efficacy of Medical Marijuana in the Treatment of Cancer-Related Pain

Background: The opioid epidemic has spurred investigations for nonopioid options, yet limited research persists on medical marijuana's (MMJ) efficacy in managing cancer-related symptoms. Objective: We sought to characterize MMJ's role on symptomatic relief and opioid consumption in the oncologic population. Design: Retrospective chart review of MMJ-certified oncology patients was performed. Divided patients into MMJ use [MMJ(+)] versus no use [MMJ(−)], and Edmonton Symptom Assessment System [...]

Mené en Thaïlande sur 141 patients atteints d'un cancer, cet essai randomisé compare l'efficacité de l'aprépitant et d'un régime combinant olanzapine (2 dosages : 10 ou 5 mg), ondansétron et dexaméthasone pour prévenir les nausées et vomissements induits par une chimiothérapie hautement émétisante

Randomized, double-blind, placebo-controlled study of aprepitant versus two dosages of olanzapine with ondansetron plus dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients receiving high-emetogenic chemotherapy

Ithimakin, Suthinee ; Theeratrakul, Pathra ; Laocharoenkiat, Apirom ; Nimmannit, Akarin ; Akewanlop, Charuwan ; Soparattanapaisarn, Nopadol ; Techawattanawanna, Sirisopa ; Korphaisarn, Krittiya ; Danchaivijitr, Pongwut

Purpose : We assessed the efficacy of aprepitant (APR) or 10 or 5 mg OLN (OLN10 or OLN5) plus ondansetron and dexamethasone for chemotherapy-induced nausea/vomiting (CINV) prophylaxis in patients receiving high-emetogenic chemotherapy (HEC). Methods : Patients who received doxorubicin + cyclophosphamide or cisplatin were given intravenous ondansetron and dexamethasone prior to chemotherapy and oral dexamethasone on days 2–4 and randomized 1:1:1 to receive APR125 on day 1 and APR80 on days 2–3 [...]

Menée aux Etats-Unis à partir de données portant sur 141 patientes ayant survécu à un cancer du sein et sur 2 086 témoins, cette étude de cohorte multiethnique analyse l'évolution de leur qualité de vie durant les 10 années suivant le diagnostic

Health-related quality of life among breast cancer survivors and noncancer controls over 10 years: Pink SWAN

Avis, Nancy E. ; Levine, Beverly ; Goyal, Neha ; Crawford, Sybil L. ; Hess, Rachel ; Colvin, Alicia ; Bromberger, Joyce T. ; Greendale, Gail A.

Background : The goal of this study was to compare health-related quality of life (HRQL) from diagnosis to 10 years postdiagnosis among breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different HRQL trajectories. Methods : Our analysis included 141 BCS and 2086 controls from the Study of Women's Health Across the Nation (SWAN), a multiracial/ethnic cohort study of mid-life women assessed approximately annually from 1995 to [...]

Cette étude américaine présente une estimation de l'incidence du cancer colorectal et de la mortalité pour l'année 2020

Colorectal cancer statistics, 2020

Siegel, Rebecca L. ; Miller, Kimberly D. ; Goding Sauer, Ann ; Fedewa, Stacey A. ; Butterly, Lynn F. ; Anderson, Joseph C. ; Cercek, Andrea ; Smith, Robert A. ; Jemal, Ahmedin

Colorectal cancer (CRC) is the second most common cause of cancer death in the United States. Every 3 years, the American Cancer Society provides an update of CRC occurrence based on incidence data (available through 2016) from population‐based cancer registries and mortality data (through 2017) from the National Center for Health Statistics. In 2020, approximately 147,950 individuals will be diagnosed with CRC and 53,200 will die from the disease, including 17,930 cases and 3,640 deaths in [...]

Menée au Danemark à partir de données portant sur 51 enfants atteints d'une leucémie lymphoblastique aiguë diagnostiquée entre 2015 et 2018, cette étude prospective analyse l'effet de changements du microbiote intestinal sur la toxicité gastrointestinale d'une chimiothérapie d'induction

Gastrointestinal toxicity during induction treatment for childhood acute lymphoblastic leukemia: the impact of the gut microbiota

De Pietri, Silvia ; Ingham, Anna Cäcilia ; Frandsen, Thomas Leth ; Rathe, Mathias ; Krych, Lukasz ; Castro Mejia, Josue Leonardo ; Nielsen, Dennis Sandris ; Nersting, Jacob ; Wehner, Peder Skov ; Schmiegelow, Kjeld ; Hasle, Henrik ; Pamp, Sünje Johanna ; Müller, Klaus

Intestinal mucositis is a common side effect of chemotherapy leading to diarrhea, abdominal pain and increased risk of infections. The intestinal microbiota has been recognized as a key regulator of mucosal immune responses. Therefore, we hypothesized that intestinal microbial changes would be associated with enterocyte loss and systemic inflammation during induction treatment for childhood acute lymphoblastic leukemia (ALL). We prospectively included 51 children newly-diagnosed with ALL [...]

Menée dans 153 pays à partir de données portant sur 4 351 patients atteints d'un rétinoblastome (âge médian au diagnostic : 30,5 ans), cette étude de cohorte analyse les facteurs liés au diagnostic (âge du patient, antécédents familiaux, stade de la tumeur, etc...) et examine les disparités dans l'incidence de la maladie selon le niveau de revenu du pays

Global Retinoblastoma Presentation and Analysis by National Income Level

Global Retinoblastoma Study Group

Importance : Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child’s life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives : To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and [...]

Menée dans l'Etat du Maine à partir de données portant sur 1 223 006 participants, cette étude analyse l'association entre la ruralité, un indicateur de défavorisation de la zone géographique, la prévalence du cancer du poumon et la mortalité

Area Deprivation Index and Rurality in Relation to Lung Cancer Prevalence and Mortality in a Rural State

Fairfield, Kathleen M ; Black, Adam W ; Ziller, Erika C ; Murray, Kimberly ; Lucas, F Lee ; Waterston, Leo B ; Korsen, Neil ; Ineza, Darlene ; Han, Paul K J

We sought to describe lung cancer prevalence and mortality in relation to socioeconomic deprivation and rurality.We conducted a population-based cross-sectional analysis of: prevalent lung cancers from a statewide all-payer claims dataset 2012-2016, lung cancer deaths in Maine from the state death registry 2012-2016, rurality, and area deprivation index (ADI), a geographic area-based measure of socioeconomic deprivation. Analyses examined rate ratios for lung cancer prevalence and mortality [...]

Menée aux Etats-Unis à partir de données portant sur un total de 14 168 patients ayant survécu à un cancer de la prostate non métastatique diagnostiqué entre 1992 et 1993 et en 2015, cette étude de cohorte analyse l'association entre une consommation de viande rouge, de viandes transformées, de volaille, de poisson et d'oeufs, et la mortalité toutes causes confondues ainsi que la mortalité spécifique (7 450 décès au total)

Red and processed meat, poultry, fish and egg intakes and cause-specific and all-cause mortality among men with non-metastatic prostate cancer in a US Cohort

Wang, Ying ; Jacobs, Eric J. ; Shah, Roma A ; Stevens, Victoria L. ; Gansler, Ted ; McCullough, Marjorie L

Background: Research on the relationship of meat, fish and egg consumption and mortality among prostate cancer survivors is limited. Methods: In the Cancer Prevention Study-II Nutrition Cohort, men diagnosed with non-metastatic prostate cancer between baseline in 1992/1993 and 2015 were followed for mortality until 2016. Analyses of pre- and post-diagnosis intakes of red and processed meat, poultry, fish, and eggs included 9,286 and 4,882 survivors, respectively. Multivariable-adjusted relative [...]

Menée à partir de données néerlandaises et norvégiennes portant au total sur 21 196 patients atteints d'un cancer colorectal métastatique incurable, cette étude identifie les traitements reçus et évalue, en fonction de l'âge des patients (âge inférieur ou supérieur ou égal à 75 ans), l'effet des stratégies thérapeutiques mises en place sur la survie globale des patients

Treatment strategies and overall survival for incurable metastatic colorectal cancer - a EURECCA international comparison including 21,196 patients from the Netherlands and Norway

Breugom, A. J. ; Bastiaannet, E. ; Guren, M. G. ; Kørner, H. ; Boelens, P. G. ; Dekker, F. W. ; Kapiteijn, E. ; Gelderblom, H. ; Larsen, I. K. ; Liefers, G. J. ; van de Velde, C. J. H.

Background : The potential benefit of surgery of the primary tumour in patients with asymptomatic metastatic colorectal cancer is debated. This EURECCA international comparison analyses treatment strategies and overall survival in the Netherlands and Norway in patients with incurable metastatic colorectal cancer. Methods : National cohorts (2007 – 2013) from the Netherlands and Norway including all patients with synchronous metastatic colorectal cancer were compared on treatment strategy and [...]

Menée aux Pays-Bas à partir de données portant sur 1 998 patients atteints d'un cancer colorectal de stade I à III diagnostiqué entre 2006 et 2015, cette étude analyse l'association entre la masse des muscles squelettiques abdominaux, la répartition du tissu adipeux (tissu adipeux viscéral et adipeux sous-cutané) et la mortalité selon le sexe

Associations of skeletal muscle mass, fat mass and mortality among men and among women with stage I-III colorectal cancer

van Baar, Harm ; Winkels, Renate M. ; Brouwer, Jesca G.M. ; Posthuma, Liesbeth ; Bours, Martijn J.L. ; Weijenberg, Matty P. ; Boshuizen, Hendriek C. ; van Zutphen, Moniek ; van Duijnhoven, Franzel J.B. ; Kok, Dieuwertje E ; Wesselink, Evertine ; Slooter, Gerrit D. ; Spillenaar Bilgen, Ernst J ; Hansson, Birgitta M.E ; de Wilt, Johannes H.W. ; Kampman, Ellen ; Beijer, Sandra

Background: The associations of abdominal skeletal muscle mass index (SMI), visceral and subcutaneous adipose tissue (VAT and SAT respectively) and mortality among stage I-III colorectal cancer (CRC) patients may differ for men and women, but only few studies stratified their data into men and women. We investigated associations of abdominal SMI, VAT and SAT with overall mortality among men and among women with stage I-III CRC. Methods: SMI, VAT and SAT were assessed from abdominal computed [...]

Menée à un niveau international à partir de données de 38 pays, cette étude analyse l'évolution de l'incidence du cholangiocarcinome intra et extrahépatique sur la période 1993-2012

Global incidence of and trends in intrahepatic and extrahepatic cholangiocarcinoma from 1993 to 2012

Florio, Andrea A. ; Ferlay, Jacques ; Znaor, Ariana ; Ruggieri, David ; Alvarez, Christian S. ; Laversanne, Mathieu ; Bray, Freddie ; McGlynn, Katherine A. ; Petrick, Jessica L.

Background : Intrahepatic cholangiocarcinomas (ICCs) and extrahepatic cholangiocarcinomas (ECCs) are highly lethal bile duct tumors. Their incidence can be difficult to estimate because of changes in cancer coding over time. No studies to date have examined their global incidence and trends with high‐quality topography‐ and histology‐specific cancer registry data. Therefore, this study examined ICC and ECC incidence with the Cancer Incidence in Five Continents Plus database. Methods : Regional [...]

Menée en Chine à partir de données portant sur 135 patients atteints d'un cancer colorectal, cette étude rétrospective analyse l'association entre leur anxiété, leurs besoins en soins de support et le délai avant le début de la chimiothérapie adjuvante

High level of unmet needs and anxiety are associated with delayed initiation of adjuvant chemotherapy for colorectal cancer patients

Zhu, Li ; Tong, Yi Xin ; Xu, Xiang Shang ; Xiao, Ai Tang ; Zhang, Yu Jie ; Zhang, Sheng

Aims : Adjuvant chemotherapy is recommended for patients with curatively resected colorectal cancer. The aim of this study is to evaluate the impact of unmet supportive care needs and anxiety on the initiation of postoperative adjuvant chemotherapy in colorectal cancer patients. Methods : This is a retrospective study from a single tertiary referral hospital. Patients diagnosed with colorectal cancer who met the inclusion criteria were included. The Hospital Anxiety and Depression Scale (HADS) [...]

Menée en Arabie Saoudite par entretiens auprès de 151 patients atteints d'un cancer et de 20 oncologues, cette étude analyse la communication entre le médecin et son patient au sujet de la stratégie thérapeutique et évalue la concordance de compréhension du protocole de chimiothérapie

Analysis of Patient-Physician Concordance in the Understanding of Chemotherapy Treatment Plans Among Patients With Cancer

Almalki, Hani ; Absi, Ahmed ; Alghamdi, Abdulrahman ; Alsalmi, Mohammed ; Khan, Muhammad

Importance : The treatment plans of patients with cancer involve multiple modalities that oncologists need to explain to patients. One such modality is chemotherapy, in which information about the goals, duration, and expected complications of therapy are considered fundamental to achieving optimal patient understanding. Therefore, effective communication between patients and their treating physicians is important to ensure patient adherence to treatment and achieve better outcomes. Objective : [...]

Mené sur 25 patients atteints d'un cancer de stade avancé et traités dans une unité de soins palliatifs, cet essai randomisé évalue l'efficacité d'une neurostimulation électrique transcutanée pour réduire l'intensité de la douleur

Transcutaneous electrical nerve stimulation for advanced cancer pain inpatients in specialist palliative care—a blinded, randomized, sham-controlled pilot cross-over trial

Siemens, Waldemar ; Boehlke, Christopher ; Bennett, Michael I. ; Offner, Klaus ; Becker, Gerhild ; Gaertner, Jan

Purpose : Transcutaneous electrical nerve stimulation (TENS) is a treatment option for cancer pain, but the evidence is inconclusive. We aimed to evaluate the efficacy and safety of TENS. Methods : A blinded, randomized, sham-controlled pilot cross-over trial (NCT02655289) was conducted on an inpatient specialist palliative care ward. We included adult inpatients with cancer pain ≥ 3 on an 11-point numerical rating scale (NRS). Intensity-modulated high TENS (IMT) was compared with placebo TENS [...]