Menée au Canada à partir de données portant sur 3 030 femmes atteintes d'un cancer du sein et sur 3 402 témoins (âge moyen au diagnostic : 56,2 ans), cette étude analyse l'association entre un apport en fer et le risque de développer la maladie, en fonction du statut ménopausique et des récepteurs hormonaux ER/PR, puis examine l'effet de polymorphismes génétiques liés au stress oxydatif (MnSOD, GSTM1 et GSTT1) sur cette association

Iron intake, oxidative stress-related genes and breast cancer risk

Chang, Vicky C. ; Cotterchio, Michelle ; Bondy, Susan J. ; Kotsopoulos, Joanne

Iron has been suggested to contribute to breast cancer development through oxidative stress generation. Our study investigated associations between iron intake and breast cancer risk, overall and by menopausal and estrogen receptor/progesterone receptor (ER/PR) status, and modification by oxidative stress-related genetic polymorphisms (MnSOD, GSTM1 and GSTT1). A population-based case–control study (3,030 cases and 3,402 controls) was conducted in Ontario, Canada. Iron intake (total, dietary, [...]

Menée aux Etats-Unis par questionnaire auprès de 183 548 femmes ménopausées (durée moyenne de suivi : 12,8 ans), cette étude analyse l'association entre un apport alimentaire de produits de glycation avancée (présents dans les aliments riches en graisses et hautement transformés) et le risque de cancer du sein invasif après la ménopause (9 851 cas)

Dietary advanced glycation end products and the risk of postmenopausal breast cancer in the National Institutes of Health-AARP Diet and Health Study

Peterson, Lindsay L. ; Park, Seho ; Park, Yikyung ; Colditz, Graham A. ; Anbardar, Narges ; Turner, David P.

Background: Advanced glycation end products (AGEs) are reactive metabolites produced as a by-product of sugar metabolism and are consumed through the diet in high-fat and highly processed foods. They are associated with chronic inflammatory diseases, and evidence suggests that they play a role in carcinogenesis. The authors evaluated the association of dietary AGE intake and the risk of postmenopausal invasive breast cancer. Methods: This was a prospective cohort study of 183,548 postmenopausal [...]

A partir d'une revue systématique de la littérature publiée entre 1993 et 2017 (1 298 articles), cette étude fait le point sur les méthodes d'évaluation de l'exposition professionnelle aux pesticides dans les études épidémiologiques

Systematic review of methods used to assess exposure to pesticides in occupational epidemiology studies, 1993–2017

Ohlander, Johan ; Fuhrimann, Samuel ; Basinas, Ioannis ; Cherrie, John W ; Galea, Karen S ; Povey, Andrew C ; van Tongeren, Martie ; Harding, Anne-Helen ; Jones, Kate ; Vermeulen, Roel ; Kromhout, Hans

Objective: Numerous exposure assessment methods (EAM) exist for investigating health effects of occupational exposure to pesticides. Direct (eg, biomonitoring) and indirect methods (eg, self-reported exposures) are however associated with degrees of exposure misclassification. We systematically reviewed EAM in studies of occupational pesticide exposure. Methods: We searched for articles reporting observational epidemiological studies in MEDLINE and Embase published 1993 to 2017. The relative [...]

Menée au Royaume-Uni à partir de données 1962-2010 du registre des cancers pédiatriques portant sur 5 369 patients atteints d'un sarcome et sur 5 380 témoins, cette étude analyse l'association entre une exposition professionnelle du père à différents agents potentiellement cancérogènes et le risque de développer la maladie chez l'enfant

Case–control study of paternal occupational exposures and childhood bone tumours and soft-tissue sarcomas in Great Britain, 1962–2010

Kendall, Gerald M. ; Bunch, Kathryn J. ; Stiller, Charles A. ; Vincent, Timothy J. ; Murphy, Michael F. G.

Background: This nationwide study investigated associations between paternal occupational exposure and childhood bone tumours and soft- tissue sarcomas. Methods: The UK National Registry of Childhood Tumours provided cases of childhood sarcomas born and diagnosed in Great Britain, 1962–2010. Control births, unaffected by childhood cancer, were matched on sex, birth period and birth registration sub-district. Fathers’ occupations were assigned to one or more of 33 exposure groups and coded for [...]

Menée en Chine à partir de données de 295 registres des cancers sur la période 2006-2014, cette étude analyse l'association entre une exposition aux particules fines PM2,5 et l'incidence annuelle des cancers de la trachée, des bronches et du poumon, à l'échelle nationale et en fonction du sexe

Ambient PM2.5 and Annual Lung Cancer Incidence: A Nationwide Study in 295 Chinese Counties

Guo, Huagui ; Li, Weifeng ; Wu, Jiansheng

Most studies have examined PM2.5 effects on lung cancer mortalities, while few nationwide studies have been conducted in developing countries to estimate the effects of PM2.5 on lung cancer incidences. To fill this gap, this work aims to examine the effects of PM2.5 exposure on annual incidence rates of lung cancer for males and females in China. We performed a nationwide analysis in 295 counties (districts) from 2006 to 2014. Two regression models were employed to analyse data controlling for [...]

Menée en Iran à l'aide de 800 détecteurs placés à l'intérieur des maisons dans 22 régions de la ville de Téhéran, cette étude analyse la dose efficace annuelle de radon 222 et le risque associé de cancer du poumon

Assess the annual effective dose and contribute to risk of lung cancer caused by internal radon 222 in 22 regions of Tehran, Iran using geographic information system

Mirdoraghi, Mohammad ; Einor, Daniel ; Baghal Asghari, Farzaneh ; Esrafili, Ali ; Heidari, Neda ; Mohammadi, Ali Akbar ; Yousefi, Mahmood

Radon gas is one of the most influential sources of indoor exposure. All its physical properties together make it a significant risk factor for lung cancer in the population. The research aims are outlined as (1) to measure the radon concentration in Tehran city and compare results with the international standards (2) to determine spatial distribution of radon gas concentration using Geographical Information System (GIS) software and (3) to estimate the annual effective dose and potential risk [...]

Menée aux Etats-Unis sur la période 2009-2012 à l'aide du génotypage de tissus prélevés sur 690 femmes atteintes de lésions cervicales intra-épithéliales de haut grade (au moins CIN2+), cette étude identifie les génotypes du papillomavirus humain associés à ces lésions

Identification of HPV genotypes causing cervical precancer using tissue-based genotyping

Venetianer, Rebecca ; Clarke, Megan A. ; van der Marel, Jacolien ; Tota, Joseph ; Schiffman, Mark ; Dunn, Samuel Terence ; Walker, Joan ; Zuna, Rosemary ; Quint, Wim ; Wentzensen, Nicolas

Identification of high-risk human papillomavirus genotypes causing cervical precancer is crucial for informing HPV vaccine development and efficacy studies, and for determining which types to include in next-generation genotyping assays. Co-occurrence of hrHPV infections is common and complicates carcinogenicity assessment; accurate attribution requires tissue-based genotyping of precancers. We included all women with cervical intraepithelial neoplasia Grade 2 or worse (CIN2+) from the Biopsy [...]

Menée à partir de données portant sur 18 226 personnes porteuses d'une mutation d'un gène de réparation des mésappariements de l'ADN ou syndrome de Lynch, cette étude analyse si le risque de cancer dépend du sexe du parent porteur de la mutation

Do the risks of Lynch syndrome-related cancers depend on the parent of origin of the mutation?

Gemechu, Shimelis Dejene ; van Vliet, Christine M. ; Win, Aung Ko ; Figueiredo, Jane C. ; Le Marchand, Loic ; Gallinger, steven ; Newcomb, Polly A. ; Hopper, John L. ; Lindor, Noralane M. ; Jenkins, Mark A. ; Dowty, James G.

Individuals who carry pathogenic mutations in DNA mismatch repair (MMR) genes have high risks of cancer, and small studies have suggested that these risks depend on the sex of the parent from whom the mutation was inherited. We have conducted the first large study of such a parent-of-origin effect (POE). Our study was based on all MMR gene mutation carriers and their relatives in the Colon Cancer Family Registry, comprising 18,226 people. The POE was estimated as a hazard ratio (HR) using a [...]

Menée aux Etats-Unis à l'aide de données sur les polymorphismes nucléotidiques et d'échantillons sanguins prélevés auprès de 2 404 patients pédiatriques atteints d'un neuroblastome et de 9 310 témoins, puis répliquée dans une cohorte indépendante de 930 cas et 3 611 témoins, cette étude analyse l'association entre des haplogroupes d'ADN mitochondrial et le risque de développer la maladie

Mitochondrial DNA haplogroups and susceptibility to neuroblastoma

Chang, Xiao ; Bakay, Marina ; Liu, Yichuan ; Glessner, Joseph ; Rathi, Komal S ; Hou, Cuiping ; Qu, Huiqi ; Vaksman, Zalman ; Nguyen, Kenny ; Sleiman, Patrick M A ; Diskin, Sharon J ; Maris, John M ; Hakonarson, Hakon

Neuroblastoma is a childhood malignancy that arises from the developing sympathetic nervous system. Although mitochondrial dysfunctions have been implicated in the pathophysiology of neuroblastoma, the role of mitochondrial DNA (mtDNA) has not been extensively investigated.2,404 Caucasian children diagnosed with neuroblastoma and 9,310 ancestry-matched controls were recruited at the Children’s Hospital of Philadelphia. The mtDNA haplogroups were identified from SNP array data of two independent [...]

A partir d'une revue systématique de la littérature publiée entre janvier 1980 et novembre 2019 (18 études), cette méta-analyse identifie les biais dans l'association établie par les données épidémiologiques entre le travail posté et le risque de cancer de la prostate

Shift Work and Prostate Cancer: An Updated Systematic Review and Meta-Analysis

Rivera-Izquierdo, Mario ; Martínez-Ruiz, Virginia ; Castillo-Ruiz, Elena Mercedes ; Manzaneda-Navío, Miriam ; Pérez-Gómez, Beatriz ; Jimenez-Moleón, Jose Juan

The International Agency of Research in Cancer (IARC) has recently confirmed shift work as a type 2A carcinogen. The results presented in published epidemiological studies regarding prostate cancer are inconsistent and the association remains controversial. The aims of this study were: (a) to investigate the possible association between shift work and prostate cancer incidence, identifying possible sources of heterogeneity; and (b) to analyze the potential effect of publication bias. A search [...]