Menée aux Etats-Unis auprès de 911 personnes ayant survécu à un cancer diagnostiqué pendant l'enfance (âge moyen : 34 ans), cette étude analyse l'association entre l'insomnie et les performances cognitives (raisonnement verbal, mémoire, attention, fonction exécutive et vitesse de traitement)

Insomnia and neurocognitive functioning in adult survivors of childhood cancer

Olsson, Ingrid Tonning ; Lubas, Margaret M ; Li, Chenghong ; Mandrell, Belinda N ; Banerjee, Pia ; Howell, Carrie R ; Ness, Kirsten K ; Srivastava, Deokumar ; Robison, Leslie L ; Hudson, Melissa M ; Krull, Kevin R ; Brinkman, Tara M

In non-cancer populations, insomnia is known to affect neurocognitive processes. Although the prevalence of insomnia appears to be elevated in survivors of childhood cancer, relatively little is known about its association with neurocognitive performance in this at-risk population.911 survivors (51.9% female; mean[SD] age 34[9.0] years; time since diagnosis 26[9.1] years) completed direct assessments of attention, memory, processing speed, and executive functioning and self-reported symptoms of [...]

Menée aux Etats-Unis à partir de données 2001-2015 portant sur 21 721 patientes atteintes d'un cancer épithélial de l'ovaire, cette étude analyse les disparités dans la survie globale en fonction de l'origine ethnique

Racial and ethnic disparities in the overall survival of women with epithelial ovarian cancer in Florida, 2001–2015

Westrick, Ashly ; Schlumbrecht, Matthew ; Hlaing, WayWay M. ; Kobetz, Erin K. ; Feaster, Daniel ; Balise, Raymond

Many studies have focused on white and black disparities in epithelial ovarian cancer (EOC) but fewer include Hispanics. Florida presents a unique opportunity to study racial/ethnic disparities. This study examined racial/ethnic disparities in the overall survival of women with EOC in Florida by histology. All EOC cases from 2001 through 2015 were identified in the Florida Cancer Database System (FCDS). Survival curves by race/ethnicity and histology were generated by Kaplan–Meier methods. Cox [...]

Menée à l'aide de données d'études d'association sur le génome entier portant sur 26 293 patientes atteintes d'un cancer épithélial de l'ovaire et sur 68 592 témoins (âge médian : 41,5-59 ans), cette étude analyse l'association entre l'inhibition génétique indirecte de la HMG-CoA réductase et le risque de développer la maladie, en général et en fonction du statut mutationel BRCA1/2

Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer

Yarmolinsky, James ; Bull, Caroline J. ; Vincent, Emma E. ; Robinson, Jamie ; Walther, Axel ; Smith, George Davey ; Lewis, Sarah J. ; Relton, Caroline L. ; Martin, Richard M.

Preclinical and epidemiological studies indicate a potential chemopreventive role of statins in epithelial ovarian cancer risk.To evaluate the association of genetically proxied inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, genetic variants related to lower function of HMG-CoA reductase, target of statins) with epithelial ovarian cancer among the general population and in BRCA1/2 mutation carriers.Single-nucleotide polymorphisms (SNPs) in HMGCR, NPC1L1, and PCSK9 [...]

Menée en Suède à l'aide de données 1958-2015 du registre des cancers portant sur 1 779 patients ayant survécu à un sarcome d'Ewing ou à un ostéosarcome (60% d'hommes ; durée de suivi : 16 170 personnes-années), cette étude analyse le risque à long terme de second cancer primitif (115 cas), par localisation

Subsequent primary neoplasms among bone sarcoma survivors; increased risks remain after 30 years of follow-up and in the latest treatment era, a nationwide population-based study

Hesla, Asle Charles ; Discacciati, Andrea ; Tsagkozis, Panagiotis ; Smedby, Karin E.

Background: The long-term risks and time trends of subsequent primary neoplasms (SPNs) among Ewing (ES) and osteosarcoma (OS) survivors are not fully understood. Methods: We performed a nationwide study of all ES and OS patients identified in the Swedish Cancer Registry from 1958 to 2015 with up to 58 years of follow-up. The risk of SPN was compared with that of the general population using standardised incidence ratios (SIRs) and absolute excess risks (AERs). Results: One hundred and fifteen [...]

Menée au Danemark à partir de données portant sur 52 723 patientes atteintes d'un cancer du sein diagnostiqué entre 1996 et 2012 (âge : au moins 20 ans ; durée de suivi : 310 583 personnes-années), cette étude analyse l'association entre une utilisation après diagnostic d'antihistaminiques H1 et le risque de cancer du sein controlatéral (1 444 cas)

The role of H1 antihistamines in contralateral breast cancer: a Danish nationwide cohort study

Bens, Annet ; Dehlendorff, Christian ; Friis, Søren ; Cronin-Fenton, Deirdre ; Jensen, Maj-Britt ; Ejlertsen, Bent ; Lash, Timothy L. ; Kroman, Niels ; Mellemkjær, Lene

Background: Preclinical studies have shown both pro- and antineoplastic effects of antihistamines. Here, we evaluated the effect of H1 antihistamines on contralateral breast cancer (CBC) risk, and whether cationic amphiphilic (CAD) antihistamines could increase the sensitivity to chemotherapy. Methods: From the Danish Breast Cancer Group clinical database, we identified all women aged ≥20 years with a first-time diagnosis of breast cancer during 1996–2012. Information on drug use, CBC and [...]

Menée à partir de données portant sur 4 086 patientes atteintes d'un cancer du sein inflammatoire non métastatique et ayant reçu un traitement systémique néoadjuvant et subi une chirurgie entre 2010 et 2015 (âge médian au diagnostic : 56 ans), cette étude évalue la réponse aux traitements et la survie globale, en fonction du statut des récepteurs hormonaux ER/HER2

Biological subtype, treatment response and outcomes in inflammatory breast cancer using data from the National Cancer Database

Kupstas, A. R. ; Hoskin, T. L. ; Day, C. N. ; Boughey, J. C. ; Habermann, E. B. ; Hieken, T. J.

Background: Although inflammatory breast cancer (IBC) is postulated to be a distinct biological entity, practice guidelines and previous data suggest that treatment and outcomes are influenced by standard approximated biological subtype. The aim of this study was validation in a large recent National Cancer Database (NCDB) patient cohort. Methods: Patients with non-metastatic IBC treated in 2010–2015 with neoadjuvant systemic therapy and surgery were identified from the NCDB. Approximated [...]

Cette étude passe en revue les aspects médicaux et les considérations éthiques concernant la préservation de la fertilité chez les enfants et adolescents atteints d'un cancer

Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations

Klipstein, Sigal ; Fallat, Mary E. ; Savelli, Stephanie

Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the [...]

Cet article fait le point sur l'accès aux médicaments anticancéreux dans le monde

Enhancing global access to cancer medicines

Cortés, Javier ; Perez-García, Jose Manuel ; Llombart-Cussac, Antonio ; Curigliano, Giuseppe ; El Saghir, Nagi S. ; Cardoso, Fatima ; Barrios, Carlos H. ; Wagle, Shama ; Roman, Javier ; Harbeck, Nadia ; Eniu, Alexandru ; Kaufman, Peter A. ; Tabernero, Josep ; García-Estévez, Laura ; Schmid, Peter ; Arribas, Joaquín

Globally, cancer is the second leading cause of death, with numbers greatly exceeding those for human immunodeficiency virus/acquired immunodeficiency syndrome, tuberculosis, and malaria combined. Limited access to timely diagnosis, to affordable, effective treatment, and to high-quality care are just some of the factors that lead to disparities in cancer survival between countries and within countries. In this article, the authors consider various factors that prevent access to cancer [...]

Menée au Royaume-Uni à l'aide d'une enquête auprès de professionnels de la recherche, cette étude identifie des priorités pour la mise en oeuvre d'essais cliniques en cancérologie et pour le suivi des patients participant aux essais

Evaluating follow-up and complexity in cancer clinical trials (EFACCT): an eDelphi study of research professionals’ perspectives

Jones, Helene Markham ; Curtis, Ffion ; Law, Graham ; Bridle, Christopher ; Boyle, Dorothy ; Ahmed, Tanweer

Objectives: To evaluate patient follow-up and complexity in cancer clinical trial delivery, using consensus methods to: (1) identify research professionals’ priorities, (2) understand localised challenges, (3) define study complexity and workloads supporting the development of a trial rating and complexity assessment tool (TRACAT). Design: A classic eDelphi completed in three rounds, conducted as the launch study to a multiphase national project (evaluating follow-up and complexity in cancer [...]

Menée aux Etats-Unis à partir de données de registres portant sur 1 622 patientes atteintes d'un cancer du sein invasif diagnostiqué entre 2009 et 2012, cette étude analyse les facteurs associés à l'accès aux tests et aux conseils génétiques pour les femmes de moins de 50 ans ayant survécu à la maladie

Disparities in BRCA counseling across providers in a diverse population of young breast cancer survivors

Reid, Sonya ; Cragun, Deborah ; Tezak, Ann ; Weidner, Anne ; Moore, Jaleesa ; Mayer, Ingrid A. ; Shu, Xiao-Ou ; Ye, Fei ; Fan, Run ; Vadaparampil, Susan ; Pal, Tuya

Purpose: All women diagnosed with breast cancer (BC) ≤age 50 should be referred for genetic counseling (GC) and testing. We sought to compare differences in provider practices and access across a racially and ethnically diverse population of young BC survivors. Methods: A registry-based sample of women diagnosed with invasive BC ≤age 50 from 2009 to 2012 was recruited through the Florida Cancer Registry, and completed a questionnaire and medical record release. Differences were compared across [...]