Menée aux Etats-Unis à l'aide de données d'incidence sur la période 2011-2015, cette étude estime la part des mélanomes cutanés attribuable à l'exposition aux ultra-violets, par état et en fonction du sexe

Cutaneous melanomas attributable to ultraviolet radiation exposure by state

Islami, Farhad ; Sauer, Ann Goding ; Miller, Kimberly D. ; Fedewa, Stacey A. ; Minihan, Adair K. ; Geller, Alan C. ; Lichtenfeld, J. Leonard ; Jemal, Ahmedin

Information on cutaneous melanoma (melanoma) burden attributable to ultraviolet (UV) radiation by state could inform state and local public health policies to mitigate the burden. We estimated numbers, proportions and age-standardized incidence rates of malignant melanomas attributable to UV radiation in each US state by calculating the difference between observed melanomas during 2011–2015 and expected cases based on historically low incidence rates among whites in Connecticut from 1942 to [...]

Menée à partir des données 1986-2016 de la cohorte "the Health Professionals Follow-Up Study" portant sur 45 185 hommes dont 563 atteints d'un cancer invasif de la vessie, cette étude analyse l'association entre la co-existence d'antécédents d'ulcère gastro-duodénal et de maladie parodontale et le risque de cancer invasif de la vessie

Gastric and duodenal ulcers, periodontal disease, and risk of bladder cancer in the Health Professionals Follow-up Study

Oh, Hannah ; Lee, Dong Hoon ; Giovannucci, Edward L. ; Keum, NaNa

Purpose : Studies suggest that peptic ulcer and periodontal disease are positively associated with bladder cancer risk. These two factors are likely to share common biologic mechanisms such as inflammation and dysbiosis. We examined the joint association of peptic ulcer (gastric/duodenal) and periodontal disease on bladder cancer risk. Methods : We conducted a prospective analysis among 45,185 men (563 invasive bladder cancer cases) in the Health Professionals Follow-Up Study (follow-up [...]

Menée aux Etats-Unis auprès de 673 patients atteints d'un carcinome hépatocellulaire et de 1 166 témoins, cette étude identifie les facteurs de risque pouvant expliquer l'augmentation du nombre de cas depuis 30 ans

Risk factors for hepatocellular carcinoma (HCC) in the northeast of the United States: results of a case–control study

Shen, Yi ; Risch, Harvey ; Lu, Lingeng ; Ma, Xiaomei ; Irwin, Melinda L. ; Lim, Joseph K. ; Taddei, Tamar ; Pawlish, Karen ; Stroup, Antoinette ; Brown, Robert ; Wang, Zhanwei ; Jia, Wei ; Wong, Linda ; Mayne, Susan T. ; Yu, Herbert

Purpose : HCC incidence has been continuously rising in the US for the past 30 years. To understand the increase in HCC risk, we conducted a case–control study in Connecticut, New Jersey and part of New York City. Methods : Through rapid case ascertainment and random digit dialing, we recruited 673 incident HCC patients and 1,166 controls. Information on demographic and anthropometric characteristics, lifestyle factors, medical and family cancer histories, were ascertained through telephone [...]

Menée en Chine auprès de 9 401 patientes atteintes d'un cancer du sein (durée médiane de suivi : 5,7 ans), cette étude analyse le risque de cancer du sein controlatéral en fonction du statut mutationnel BRCA1/2, de l'âge au premier diagnostic (plus ou moins de 40 ans), du type de traitements reçus et de l'existence d'antécédents familiaux de la maladie (181 cas)

Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers in a large cohort of unselected Chinese breast cancer patients

Su, Liming ; Xu, Ye ; Ouyang, Tao ; Li, Jinfeng ; Wang, Tianfeng ; Fan, Zhaoqing ; Fan, Tie ; Lin, Benyao ; Xie, Yuntao

To estimate the cumulative risk of contralateral breast cancer (CBC) in BRCA1/2 carriers in a large cohort of unselected Chinese breast cancer patients. Our study comprised 9,401 unselected Chinese breast cancer patients and BRCA1/2 germline mutations were determined in all patients. After a median follow-up of 5.7 years, 181 patients developed CBC in this cohort. Compared to noncarriers, BRCA1 and BRCA2 carriers had a 4.52-fold (95% CI, 2.63–7.76) and 5.54-fold (95% CI, 3.51–8.74) increased [...]