A partir d'une revue systématique de la littérature (51 articles), cette étude analyse les recommandations de bonnes pratiques concernant la prise en charge des symptômes à long terme et des déficiences fonctionnelles chez des patients ayant survécu à un cancer anal ou colorectal

Systematic review of clinical practice guidelines for colorectal and anal cancer: the extent of recommendations for managing long-term symptoms and functional impairments

Wiltink, Lisette M. ; White, K. ; King, M. T. ; Rutherford, C.

Purpose : Due to increasing numbers of colorectal and anal cancer survivors, more individuals are living with long-term symptoms after treatment. A systematic review was undertaken to assess the extent to which practice guidelines for colorectal and anal cancer provide recommendations for managing long-term symptoms and functioning impairments. Methods : Four electronic databases and websites of 30 international cancer societies were searched for clinical practice guidelines, consensus [...]

Menée aux Etats-Unis à partir de données portant sur 183 témoins et sur 736 patients ayant survécu plus de 2 ans à un cancer hématologique et ayant reçu une greffe de moelle osseuse ou une transfusion de sang entre 1974 et 2014 (âge supérieur à 60 ans lors des traitements), cette étude de cohorte analyse la sévérité de leur fatigue

Pain in older survivors of hematologic malignancies after blood or marrow transplantation: A BMTSS report

Farrukh, Naveed ; Hageman, Lindsey ; Chen, Yanjun ; Wu, Jessica ; Ness, Emily ; Kung, Michelle ; Francisco, Liton ; Parman, Mariel ; Landier, Wendy ; Arora, Mukta ; Armenian, Saro ; Bhatia, Smita ; Williams, Grant R.

Background : Blood or marrow transplantation (BMT) is increasingly offered to older adults with hematologic malignancies; however, their risk for severe pain is poorly understood. Using the Bone Marrow Transplant Survivor Study, the current study investigated the prevalence and predictors of pain after BMT (allogeneic or autologous) as well as its association with physical performance impairments and frailty. Methods : The cohort included 736 patients with hematologic malignancies who underwent [...]

Menée en Nouvelle-Zélande à partir de données portant sur 51 patientes ayant survécu à un cancer du sein, cette étude analyse l'efficacité d'exercices d'entraînement de résistance sur une période de 12 semaines pour améliorer la santé musculaire et cardiorespiratoire

Circuit resistance training and cardiovascular health in breast cancer survivors

Jones, Lynnette M. ; Stoner, Lee ; Baldi, J. Chris ; McLaren, Blair

Objective : Cardiovascular disease is the leading cause of death in breast cancer survivors. While evidence shows circuit resistance training (CRT) is effective for improving muscle and cardiorespiratory fitness, whether CRT is an efficacious therapy for decreasing cardiovascular risk in cancer survivors is unclear. Methods : Fifty‐one breast cancer survivors were recruited to either 12 weeks CRT (n = 26), or a non‐exercising wait‐list control (n = 25). Two supervised 60 min CRT sessions per [...]

Mené sur 44 patientes atteintes d'un cancer du sein, cet essai de phase II évalue l'efficacité de la cryothérapie pour prévenir une neuropathie périphérique et les effets indésirables dermatologiques induits par le paclitaxel

Cryotherapy for the prevention of weekly paclitaxel-induced peripheral adverse events in breast cancer patients

Shigematsu, Hideo ; Hirata, Taizo ; Nishina, Mai ; Yasui, Daisuke ; Ozaki, Shinji

Purpose : This randomized phase II study was conducted to investigate the efficacy of cryotherapy in preventing peripheral neuropathy and dermatological adverse events in breast cancer patients treated with weekly paclitaxel. Methods : Patients treated with 12 weekly doses of paclitaxel for breast cancer were randomized (1:1) into a cryotherapy or control group. The primary endpoint was the percentage of patients with a marked decrease in the Functional Assessment of Cancer [...]

Menée dans 41 pays sur la période 1998-2012, cette étude internationale analyse l'évolution de l'incidence des cancers chez les adolescents et jeunes adultes

International trends in the incidence of cancer among adolescents and young adults

Gupta, Sumit ; Harper, Andrew ; Ruan, Yibing ; Barr, Ronald ; Frazier, A Lindsay ; Ferlay, Jacques ; Steliarova-Foucher, Eva ; Fidler-Benaoudia, Miranda M

Background : Although adolescent and young adult (AYA) cancers represent a unique spectrum of malignancies, epidemiologic studies of cancer incidence often group AYAs together with younger or older populations, obscuring patterns specific to this population. Methods : We examined AYA cancer incidence trends in 41 countries over a 15-year period using the CI5plus database. Truncated age-standardized incidence rates were calculated and the annual percentage change (APC) was assessed, with [...]

Menée aux Etats-Unis en 2018 par enquête auprès de centres de cancérologie désignés ou non par l'Institut national du cancer, cette étude analyse les changements dans les services de soins palliatifs au cours des dix dernières années

State of palliative care services at US cancer centers: An updated national survey

Hui, David ; De La Rosa, Allison ; Chen, Joseph ; Dibaj, Seyedeh ; Delgado Guay, Marvin ; Heung, Yvonne ; Liu, Diane ; Bruera, Eduardo

Background: This study examined the changes in outpatient palliative care services at US cancer centers over the past decade. Methods: Between April and August 2018, all National Cancer Institute (NCI)–designated cancer centers and a random sample of 1252 non–NCI-designated cancer centers were surveyed. Two surveys used previously in a 2009 national study were sent to each institution: a 22-question cancer center executive survey regarding palliative care infrastructure and attitudes toward [...]

Menée en Allemagne à partir des données de 3 registres des cancers portant sur 22 905 patients atteints d'un cancer du poumon diagnostiqué entre 2000 et 2015, cette étude analyse l'association entre des facteurs socioéconomiques locaux et la survie

Socioeconomic differences and lung cancer survival in Germany: Investigation based on population-based clinical cancer registration

Finke, Isabelle ; Behrens, Gundula ; Schwettmann, Lars ; Gerken, Michael ; Pritzkuleit, Ron ; Holleczek, Bernd ; Brenner, Hermann ; Jansen, Lina

Objectives : Studies from several countries reported socioeconomic inequalities in lung cancer survival. Hypothesized reasons are differences in cancer care or tumor characteristics. We investigated associations of small-area deprivation and lung cancer survival in Germany and the possible impact of differences in patient, tumor or treatment factors. Materials and Methods : Patients registered with a primary tumor of the lung between 2000-2015 in three German population-based clinical cancer [...]

Menée auprès de 4 485 patients atteints d'un cancer hématologique et ayant subi une greffe de cellules souches hématopoïétiques entre 1976 et 2014 (âge médian au moment de la greffe : 38,8 ans ; 56% d'hommes), cette étude estime le taux de survie conditionnel à 5 ans, compare les risques de décès toutes causes confondues et par cancer à ceux de la population générale et identifie les facteurs associés à la mortalité tardive non liée à la maladie

Conditional Survival, Cause-specific Mortality, Risk Factors of Late Mortality After Allogeneic Hematopoietic Cell Transplantation

Wong, F Lennie ; Berano, Jennifer ; Atencio, Liezl ; Stiller, Tracey ; Kim, Heeyoung ; Chanson, Dayana ; Forman, Stephen J ; Nakamura, Ryotaro ; Armenian, Saro H

Long-term mortality after hematopoietic cell transplantation (HCT) is conventionally calculated from the time of HCT, ignoring temporal changes in survivors’ mortality risks. Conditional survival rates, accounting for time already survived, are relevant for optimal delivery of survivorship care, but have not been widely quantified. We estimated conditional survival by elapsed survival time in allogeneic HCT patients and examined cause-specific mortality.We calculated conditional survival rates [...]

Mené aux Etats-Unis à partir de données portant sur 48 835 femmes âgées de 50 à 79 ans, cet essai randomisé évalue l'association à long terme entre des modifications de comportements alimentaires (adhésion à un régime alimentaire pauvre en graisses comportant des légumes, des fruits et des céréales) et le risque de cancer du sein ainsi que la mortalité spécifique (durée médiane de suivi : 19,6 ans)

Dietary Modification and Breast Cancer Mortality: Long-Term Follow-Up of the Women’s Health Initiative Randomized Trial

Rowan T. Chlebowski ; Aaron K. Aragaki ; Garnet L. Anderson ; Kathy Pan ; Marian L. Neuhouser ; JoAnn E. Manson ; Cynthia A. Thomson ; Yasmin Mossavar-Rahmani ; Dorothy S. Lane ; Karen C. Johnson ; Jean Wactawski-Wende ; Linda Snetselaar ; Thomas E. Rohan ; Juhua Luo ; Ana Barac ; Ross L. Prentice ; on behalf of the Women’s Health Initiative

PURPOSE : Observational studies of dietary fat intake and breast cancer have reported inconsistent findings. This topic was addressed in additional analyses of the Women’s Health Initiative (WHI) Dietary Modification (DM) clinical trial that evaluated a low-fat dietary pattern influence on breast cancer incidence. METHODS : In the WHI DM trial, 48,835 postmenopausal women, ages 50-79 years, with no prior breast cancer, and a dietary fat intake of ≥ 32% of energy were randomly assigned at 40 US [...]

Menée au Canada par questionnaire auprès de 289 patients atteints d'un cancer de stade avancé, cette étude analyse l'association entre la communication au sein du couple, la sécurité de l'attachement et la préparation au décès

The Impact of Attachment Security on Death Preparation in Advanced Cancer: The Role of Couple Communication

Mah, Kenneth ; Shapiro, Gilla K. ; Hales, Sarah ; Rydall, Anne ; Malfitano, Carmine ; An, Ekaterina ; Nissim, Rinat ; Li, Madeline ; Zimmermann, Camilla ; Rodin, Gary

Objective : Attachment security protects psychological well‐being in patients with advanced cancer, but its effect on death preparation in this population has not been demonstrated. We examined the relationship of attachment security to death preparation in advanced cancer and tested whether couple communication mediates this relationship and whether gender and age moderate this mediating effect, using longitudinal data from a psychotherapy trial. Methods : Patients with advanced cancer who [...]

Menée au Canada, cette étude analyse l'intérêt d'un outil permettant de détecter la peur de la récidive chez des patients ayant survécu à un cancer

The FCR-1: Initial validation of a single-item measure of fear of cancer recurrence

Rudy, Lauren ; Maheu, Christine ; Körner, Annett ; Lebel, Sophie ; Gélinas, Céline

Objective : Fear of cancer recurrence (FCR) is characterized by the fear, worry, or concern that cancer will come back or progress. The negative effects associated with FCR are consistently identified by cancer survivors as one of their most prominent unmet needs. Current measures of FCR can be long, complex, and burdensome for survivors to complete. The objective of the present study is to develop and validate a one‐item measure of FCR. Methods : The ability of the FCR‐1 to detect change in [...]

A partir d'une revue systématique de la littérature (14 études), cette étude analyse les besoins en information, chez des patients atteints d'un cancer, concernant les tests génomiques et leurs implications thérapeutiques

Understanding and information needs of cancer patients regarding treatment-focused genomic testing: A systematic review

Wolyniec, Kamil ; Sharp, Jessica ; Lazarakis, Smaro ; Mileshkin, Linda ; Schofield, Penelope

Objective : To systematically review literature exploring experiences of cancer patients regarding their understanding of treatment‐focused genomic testing as well as their information needs and related themes. Methods : Six databases were searched for the original studies published in English language that explored patients’ understanding of the information related to the genomic testing and its implications for treatment of cancer. The Mixed‐Method Assessement Tool was used to examine the [...]

Cette étude présente le rapport annuel de l'"American Society of Clinical Oncology" incluant le diagnostic, la prévention et les traitements du cancer pour l'année 2020

Clinical Cancer Advances 2020: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology

Merry Jennifer Markham ; Kerri Wachter ; Neeraj Agarwal ; Monica M. Bertagnolli ; Susan Marina Chang ; William Dale ; Catherine S. M. Diefenbach ; Carlos Rodriguez-Galindo ; Daniel J. George ; Timothy D. Gilligan ; R. Donald Harvey ; Melissa L. Johnson ; Randall J. Kimple ; Miriam A. Knoll ; Noelle LoConte ; Robert G. Maki ; Jane Lowe Meisel ; Jeffrey A. Meyerhardt ; Nathan A. Pennell ; Gabrielle B. Rocque ; Michael S. Sabel ; Richard L. Schilsky ; Bryan James Schneider ; William D. Tap ; Robert G. Uzzo ; Shannon Neville Westin

Each year Clinical Cancer Advances: ASCO’s Annual Report on Progress Against Cancer highlights the most important clinical research advances of the past year, including the Advance of the Year, and identifies priority areas where ASCO believes research efforts should be focused moving forward. In 2020, ASCO names the Refinement of Surgical Treatment of Cancer as the Advance of the Year. Years of progress in developing new systemic cancer therapies has not only improved patient survival and [...]