Menée à l'aide de données européennes portant sur 2 009 patients atteints d'un cancer du pancréas et de 1 532 témoins, cette étude analyse l'association entre le tabagisme et le risque de développer la maladie, en fonction des caractéristiques du tabac et de différents facteurs liés aux habitudes de vie

Pancreatic cancer risk in relation to lifetime smoking patterns, tobacco type, and dose-response relationships

Molina-Montes, Esther ; Van Hoogstraten, Lisa ; Gomez-Rubio, Paulina ; Löhr, Matthias ; Sharp, Linda ; Molero, Xavier ; Marquez, Mirari ; Michalski, Christoph W ; Farré, Antoni ; Perea, José ; O'Rorke, Michael ; Greenhalf, William ; Ilzarbe, Lucas ; Tardon, Adonina ; Gress, Thomas M ; Barberá, Victor M ; Crnogorac-Jurcevic, Tatjana ; Muñoz-Bellvís, Luís ; Domínguez-Muñoz, Enrique ; Balsells, Joaquim ; Costello, Eithne ; Iglesias, Mar ; Kleeff, Jorg ; Kong, Bo ; Mora, Josefina ; O'Driscoll, Damian ; Poves, Ignasi ; Scarpa, Aldo ; Yu, Jingru ; Ye, Weimin ; Hidalgo, Manuel ; Carrato, Alfredo ; Lawlor, Rita ; Real, Francisco X ; Malats, Nuria

BACKGROUND: Despite smoking being a well-established risk factor for pancreatic cancer (PC), there is a need to further characterize PC risk according to lifespan smoking patterns and other smoking features. Our aim was to deeply investigate them within a large European case-control study. METHODS: Tobacco smoking habits and other relevant information was obtained from 2,009 cases and 1,532 controls recruited in the PanGenEU study using standardized tools. Multivariate logistic regression [...]

Menée au Japon sur la période 1993-2013 auprès d'une cohorte de 78 825 personnes (durée moyenne de suivi : 16,8 ans), cette étude analyse l'association entre une consommation d'alcool et le risque de cancer (8 486 cas dont 4386 liés à l'alcool), en fonction de la présence d'un syndrome du rougissement (dû à une déficience de l'aldéhyde déshydrogénase 2)

Impact of alcohol drinking on cancer risk with consideration of flushing response: The Japan Public Health Center-based Prospective Study Cohort (JPHC study)

Ono, Ayami ; Inoue, Manami ; Sawada, Norie ; Saito, Eiko ; Yamaji, Taiki ; Shimazu, Taichi ; Goto, Atsushi ; Iwasaki, Motoki ; Tsugane, Shoichiro

Alcohol drinking is a risk factor for cancer. The degree of risk is increased in subjects showing the flushing response, which is due to aldehyde dehydrogenase 2 (ALDH2) polymorphism. The attributable risk of alcohol drinking for cancer in Japan has not been sufficiently investigated with consideration of flushing response. We followed 78,825 Japanese in JPHC study cohort II. The association between alcohol consumption and cancer incidence was assessed according to self-reported flushing [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2019 (28 méta-analyses d'études observationnelles), cette étude analyse l'association entre une consommation de café et le risque de cancer

Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies

Zhao, Long-Gang ; Li, Zhuo-Ying ; Feng, Guo-Shan ; Ji, Xiao-Wei ; Tan, Yu-Ting ; Li, Hong-Lan ; Gunter, Marc J. ; Xiang, Yong-Bing

Background: Epidemiological studies on the association between coffee intake and cancer risk have yielded inconsistent results. To summarize and appraise the quality of the current evidence, we conducted an umbrella review of existing findings from meta-analyses of observational studies. Methods: We searched PubMed, Embase, Web of Science and the Cochrane database to obtain systematic reviews and meta-analyses of associations between coffee intake and cancer incidence. For each association, we [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2017 (29 études observationnelles), cette méta-analyse évalue l'association entre une consommation de viande transformée et le risque de cancer colorectal

Processed meat intake and incidence of colorectal cancer: a systematic review and meta-analysis of prospective observational studies

Händel, M. N. ; Rohde, J. F. ; Jacobsen, R. ; Nielsen, S. M. ; Christensen, R. ; Alexander, D. D. ; Frederiksen, P. ; Heitmann, B. L.

The objective was to use accumulated evidence to explore the association between processed meat intake and risk of colorectal cancer (CRC) and to investigate the reliability of associations by evaluating patterns of risk by study population characteristics and research quality parameters. We included 29 observational prospective cohort studies with relative risk estimates and 95% confidence intervals for CRC according to various levels of processed meat consumption. Risk of bias was assessed [...]

Menée au Danemark à partir de données de registres nationaux portant sur 108 987 témoins et sur 12 111 participants ayant étudié dans quatre écoles situées à proximité d'une usine de production d'amiante-ciment puis suivis jusqu'en 2015 (âge médian : 62,4 ans ; durée médiane de suivi : 49,3 ans), cette étude analyse l'association entre une exposition à l'amiante (environnementale ou professionnelle) et le risque de cancers hématologiques (1 125 cas)

Asbestos exposure and haematological malignancies: a Danish cohort study

Würtz, Else Toft ; Hansen, Johnni ; Røe, Oluf Dimitri ; Omland, Øyvind

Environmental asbestos exposure and occupational asbestos exposure increase the risk of several types of cancer, but the role of such exposures for haematological malignancies remains controversial. We aimed to examine the risk of haematological malignancies: first, in subjects exposed early in life, independently of any occupational exposure occurring later; second, in subjects exposed occupationally. We established an environmentally exposed cohort from four schools located near the only [...]

Menée à partir de données portant sur 1 509 patientes atteintes d'un cancer de l'ovaire après la ménopause et sur 2 295 femmes ménopausées, cette étude analyse l'association entre l'utilisation d'un traitement hormonal substitutif combiné continu (œstroprogestatif) et le risque de cancer de l'ovaire par type histologique, en fonction de la durée d'utilisation

Estrogen plus progestin hormone therapy and ovarian cancer: a complicated relationship explored

Lee, Alice W. ; Wu, Anna H. ; Wiensch, Ashley ; Mukherjee, Bhramar ; Terry, Kathryn L. ; Harris, Holly R. ; Carney, Michael E. ; Jensen, Allan ; Cramer, Daniel W. ; Berchuck, Andrew ; Doherty, Jennifer Anne ; Modugno, Francesmary ; Goodman, Marc T. ; Alimujiang, Aliya ; Rossing, Mary Anne ; Cushing-Haugen, Kara L. ; Bandera, Elisa V. ; Thompson, Pamela J. ; Kjaer, Susanne K. ; Hogdall, Estrid ; Webb, Penelope M. ; Huntsman, David G. ; Moysich, Kirstin B. ; Lurie, Galina ; Ness, Roberta B. ; Stram, Daniel O. ; Roman, Lynda ; Pike, Malcolm C. ; Pearce, Celeste Leigh ; for the Ovarian Cancer Association Consortium

Background: Menopausal estrogen–alone therapy is a risk factor for endometrial and ovarian cancers. When a progestin is included with the estrogen daily (continuous estrogen–progestin combined therapy), there is no increased risk of endometrial cancer. However, the effect of continuous estrogen–progestin combined therapy on risk of ovarian cancer is less clear. Methods: We pooled primary data from five population-based case–control studies in the Ovarian Cancer Association Consortium, including [...]

Menée en Chine à l'aide de données de l'assurance maladie portant sur 12 573 patients infectés par le virus de la dengue et sur 62 865 témoins (durée médiane de suivi : 8,22 ans), cette étude analyse l'association entre cette infection et le risque de leucémie

Risk of Leukemia after Dengue Virus Infection: A Population-Based Cohort Study

Chien, Yu-Wen ; Wang, Chia-Chun ; Wang, Yu-Ping ; Lee, Cho-Yin ; Perng, Guey Chuen

Background: Infections account for about 15% of human cancers globally. Although abnormal hematologic profiles and bone marrow suppression are common in patients with dengue, whether dengue is associated with a higher risk of leukemia has not been investigated. Methods: We conducted a nationwide population-based cohort study by analyzing the National Health Insurance Research Databases in Taiwan. Laboratory-confirmed dengue patients between 2002 and 2011 were identified; five matched non-dengue [...]

Menée au Canada auprès de 905 témoins et de 844 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre une exposition à la lumière nocturne et le risque de développer la maladie

Outdoor light at night at residences and breast cancer risk in Canada

Ritonja, Jennifer ; McIsaac, Michael A. ; Sanders, Eric ; Kyba, Christopher C. M. ; Grundy, Anne ; Cordina-Duverger, Emilie ; Spinelli, John J. ; Aronson, Kristan J.

Experimental and epidemiologic studies suggest that light at night (LAN) exposure disrupts circadian rhythm, and this disruption may increase breast cancer risk. We investigated the potential association between residential outdoor LAN and breast cancer risk. A population-based case–control study was conducted in Vancouver, British Columbia and Kingston, Ontario, Canada with incident breast cancer cases, and controls frequency matched by age in the same region. This analysis was restricted to [...]