Occupational livestock or animal dust exposure and offspring cancer risk in Denmark, 1968–2016
Menée au Danemark auprès de 123 228 témoins et de 5 078 enfants atteints d'un cancer diagnostiqué entre 1968 et 2016 (âge : moins de 17 ans), cette étude analyse l'association entre une exposition professionnelle de leurs parents à la poussière d'origine animale (élevage ou autre exposition) et le risque de développer la maladie
Résumé en anglais
Objective: To examine associations with occupational livestock or other animal dust exposure and offspring cancer risk.
Methods: In this population-based case–control study of Danish children aged < 17 years old, 5078 childhood cancer cases diagnosed 1968–2016 were matched to cancer-free controls by birth year and sex (n = 123,228). Occupational livestock or animal dust exposure was identified using a job-exposure matrix. We employed multivariable conditional logistic regression models to estimate associations with offspring cancer for births 1968–2016 and 1989–2016, with the latter timeframe reflecting a period of presumed higher exposure due to changes in Danish farming practices. Sensitivity analyses considered place of birth (urban areas vs. rural areas and small towns).
Results: For births 1968–2016, paternal exposure from offspring birth to cancer diagnosis was associated with central nervous system tumors (adjusted odds ratio [OR] = 1.30, 95% confidence interval [CI] 1.04–1.63) and germ cell tumors (OR = 1.82, 95% CI 1.05–3.27), while maternal pregnancy exposure was associated with astrocytoma (OR = 1.89, 95% CI 1.00–3.57). For births 1989–2016, paternal exposure from offspring birth to cancer diagnosis was negatively associated with acute lymphoid leukemia (OR = 0.58, 95% CI 0.33–1.00). For births in rural areas only, maternal exposure from offspring birth to cancer diagnosis was positively associated with acute myeloid leukemia (OR = 2.16, 95% CI 1.09–4.29).
Conclusions: This study suggests that paternal occupational animal exposure is associated with offspring germ cell tumors, and maternal pregnancy exposure with astrocytomas. Our results are mixed with respect to leukemia subtypes.
