Menée aux Etats-Unis auprès de 750 patients âgés atteints d'un cancer (âge médian : 72 ans), cette étude multicentrique analyse l'association entre l'indice de masse corporelle avant le traitement, le niveau d'albumine, la perte de poids non intentionnelle au cours des 6 mois précédents et le risque de toxicité de la chimiothérapie

Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors

Dotan, Efrat ; Tew, William P. ; Mohile, Supriya G. ; Ma, Huiyan ; Kim, Heeyoung ; Sun, Can-Lan ; Caan, Bette ; Dale, William ; Gajra, Ajeet ; Klepin, Heidi D. ; Owusu, Cynthia ; Gross, Cary ; Muss, Hyman ; Chapman, Andrew ; Katheria, Vani ; Hurria, Arti

Background : Nutritional status can directly affect morbidity and mortality in older adults with cancer. This study evaluated the association between pretreatment body mass index (BMI), albumin level, and unintentional weight loss (UWL) in the prior 6 months and chemotherapy toxicity among older adults with solid tumors. Methods : This was a secondary analysis of a prospective, multicenter study involving chemotherapy-treated patients 65 years old or older. Geriatric assessment, BMI, albumin [...]

Menée aux Etats-Unis par enquête auprès de 482 enfants atteints d'un cancer récemment diagnostiqué (âge : 7-18 ans) et de leurs aidants, cette étude évalue l'efficacité et la pertinence d'un outil leur permettant de déclarer leurs symptômes et de mesurer les effets indésirables des traitements anticancéreux

Validity and Reliability of the Pediatric Patient-Reported Outcomes - Common Terminology Criteria for Adverse Events

Reeve, Bryce B ; McFatrich, Molly ; Mack, Jennifer W ; Maurer, Scott H ; Jacobs, Shana S ; Freyer, David R ; Withycombe, Janice S ; Baker, Justin N ; Castellino, Sharon M ; Lin, Li ; Lucas, Nicole R ; Hinds, Pamela S

Background : Patient-reported outcome (PRO) measurements linked to Common Terminology Criteria for Adverse Events (CTCAE) grading may improve symptom adverse event (AE) reporting in pediatric oncology trials. We evaluated construct validity, responsiveness, and test-retest reliability of the Ped-PRO–CTCAE measurement system for children and adolescents undergoing cancer care. Methods : 482 children (7–18 years, 41.5% not non-Hispanic white) newly diagnosed with cancer and their caregivers [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2018, cette méta-analyse évalue l'évolution de la sévérité de la fatigue, avant, pendant et après les traitements, chez des patients atteints d'un cancer du rectum

Changes in fatigue in rectal cancer patients before and after therapy: a systematic review and meta-analysis

Wen-Pei, Chang ; Hsiu-Ju, Jen

Purpose : Fatigue is a common problem among rectal cancer patients and can affect their quality of life. This study conducted a systematic review to better understand changes in fatigue severity in rectal cancer patients before, during, and after they undergo therapy. Methods : We used preset keywords to search the Cochrane Library, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, and ProQuest databases for relevant studies published between 2000 and 2018, and data [...]

Menée à partir des données des registres américains des cancers et de la base Medicare portant sur 995 patientes atteintes d'un cancer de l'endomètre et âgées d'au moins 65 ans, cette étude analyse l'association entre la qualité de vie, mesurée avant le diagnostic, et la survie

Pre-diagnosis health-related quality of life and survival in older women with endometrial cancer

Klapheke, Amy K. ; Keegan, Theresa H. M. ; Ruskin, Rachel ; Cress, Rosemary D.

Purpose : Health-related quality of life (HRQOL) is an important prognostic factor in cancer patients. To date, no other studies have assessed the association between HRQOL measured before diagnosis and survival in older women with endometrial cancer. Methods : The Surveillance, Epidemiology, and End Results – Medicare Health Outcomes Survey linked database was used to identify 995 women who were at least 65 years old and completed a survey before diagnosis with endometrial cancer. We obtained [...]

Menée en Chine à partir de données portant sur 512 715 adultes (âge moyen : 51 ans ; durée de suivi : 10 ans ; 59% de femmes), cette étude analyse l'association entre des indicateurs du statut socioéconomique et le risque de cancer gastrointestinal (27 940 cas)

Socioeconomic status in relation to risks of major gastrointestinal cancers in Chinese adults: a prospective study of 0.5 million people

Pang, Yuanjie ; Kartsonaki, Christiana ; Guo, Yu ; Chen, Yiping ; Yang, Ling ; Bian, Zheng ; Bragg, Fiona ; Millwood, Iona Y ; Lv, Jun ; Yu, Canqing ; Chen, Junshi ; Li, Liming ; Holmes, Michael V ; Chen, Zhengming

Background: Low socioeconomic status (SES) is associated with higher risk of certain gastrointestinal (e.g. colorectal, pancreatic, and liver) cancers in Western populations. Evidence is very limited in China where correlates and determinants of SES differ from those in the West. Methods: The prospective China Kadoorie Biobank recruited 512,715 adults (59% women, mean age 51 years) from 10 (5 urban, 5 rural) regions. During 10 years of follow-up, 27,940 incident cancers (including 3061 [...]

Menée à partir de données internationales sur la période 1990-2017, cette étude analyse les disparités hommes-femmes dans l'incidence des cancers gastriques, en fonction de l'âge et du statut socioéconomique

Sex difference in incidence of gastric cancer: an international comparative study based on the Global Burden of Disease Study 2017

Lou, Lixia ; Wang, Linyan ; Zhang, Yaoyi ; Chen, Guofeng ; Lin, Lele ; Jin, Xiaoli ; Huang, Yi ; Chen, Jian

Objectives : To investigate sex difference in global gastric cancer incidence by year, age and socioeconomical status. Design : An international comparative study. Setting : We obtained the global and national sex-specific incidence of gastric caner by year and age from the Global Burden of Disease Study 2017. The human development index (HDI) in 2017 as an indicator of national socioeconomical status was extracted from the Human Development Report. Main outcome measures : Sex-specific [...]

Menée aux Etats-Unis à partir de données d'enquêtes nationales sur la période 2011-2018, cette étude analyse les tendances dans les comportements tabagiques des adolescents (fréquence, intensité, âge de la première cigarette), en fonction du sexe, du niveau scolaire et de l'origine ethnique

Trends in Smoking Behaviors Among US Adolescent Cigarette Smokers

Azagba, Sunday ; Manzione, Lauren ; Shan, Lingpeng ; King, Jessica

INTRODUCTION: Identifying trends in smoking behaviors among youth cigarette smokers could inform youth policy and interventions. METHODS: Using 2011–2018 National Youth Tobacco Survey data, logistic/linear regressions were used to analyze trends in smoking frequency, intensity, age of first cigarette use, and electronic cigarette (e-cigarette) use frequency among current smokers. Stratified analyses were conducted among male, female, middle school, and high school students and race and [...]

Menée en Angleterre à partir de données du registre des cancers portant sur 331 655 patients ayant reçu un diagnostic de cancer du côlon, du rectum, du poumon ou de lymphome de Hodgkin entre 2009 et 2013 (âge : 15-90 ans), cette étude analyse la prévalence de comorbidités en fonction du statut socio-économique

Comorbidity prevalence among cancer patients: a population-based cohort study of four cancers

Fowler, Helen ; Belot, Aurélien ; Ellis, Libby ; Maringe, Camille ; Luque-Fernandez, Miguel Angel ; Njagi, Edmund Njeru ; Navani, Neal ; Sarfati, Diana ; Rachet, Bernard

Background : The presence of comorbidity affects the care of cancer patients, many of whom are living with multiple comorbidities. The prevalence of cancer comorbidity, beyond summary metrics, is not well known. This study aims to estimate the prevalence of comorbid conditions among cancer patients in England, and describe the association between cancer comorbidity and socio-economic position, using population-based electronic health records. Methods : We linked England cancer registry records [...]

Menée au Japon par questionnaire auprès de 92 924 participants (durée moyenne de suivi : 16,8 ans), cette étude analyse l'association entre un apport en fibres alimentaires, la source de l'apport, et la mortalité toutes causes confondues (19 400 décès) et par cancer

Dietary fiber intake and total and cause-specific mortality: the Japan Public Health Center-based prospective study

Katagiri, Ryoko ; Goto, Atsushi ; Sawada, Norie ; Yamaji, Taiki ; Iwasaki, Motoki ; Noda, Mitsuhiko ; Iso, Hiroyasu ; Tsugane, Shoichiro

An inverse association has been shown between dietary fiber intake and several noncommunicable diseases. However, evidence of this effect remains unclear in the Asian population.We examined the association between dietary fiber intake and all-cause and cause-specific mortality, as well as the association between fiber intake from dietary sources and all-cause mortality.We conducted a large-scale population-based cohort study (Japan Public Health Center-based prospective study). A validated [...]

Menée au Japon par questionnaire auprès de 92 915 participants (âge : 45-74 ans ; durée moyenne de suivi : 14,8 ans), cette étude analyse l'association entre une consommation de produits à base de soja (fermenté ou non) et la mortalité toutes causes confondues (13 303 décès) et par cancer

Association of soy and fermented soy product intake with total and cause specific mortality: prospective cohort study

Katagiri, Ryoko ; Sawada, Norie ; Goto, Atsushi ; Yamaji, Taiki ; Iwasaki, Motoki ; Noda, Mitsuhiko ; Iso, Hiroyasu ; Tsugane, Shoichiro

Objective: To investigate the association between several types of soy products and all cause and cause specific mortality. Design: Population based cohort study. Setting: Japan Public Health Centre-based Prospective Study, which includes 11 public health centre areas in Japan. Participants: 92 915 participants (42 750 men and 50 165 women) aged 45 to 74 years.Exposures Intake of total soy products, fermented soy products (natto and miso), non-fermented soy products, and tofu from a five year [...]

Menée au Danemark à partir de données d'enquêtes de santé publique et de registres portant sur 3 514 personnes ayant survécu à un cancer et sur 171 262 témoins (âge moyen : 48 ans ; 40% d'hommes), cette étude analyse l'effet des antécédents de cancer ou de comorbidités sur l'association entre le niveau d'éducation et le risque d'incapacité de travail

Educational attainment and work disability in cancer survivors: Do diagnosis and comorbidity affect this association?

Stapelfeldt, Christina M. ; Duijts, Saskia F. A. ; Horsboel, Trine A. ; Momsen, Anne-Mette H. ; Andersen, Niels T. ; Larsen, Finn B. ; Friis, Karina ; Nielsen, Claus V.

Objectives: To study whether educational attainment had less impact on work disability in cancer survivors than in individuals without cancer. To study whether comorbidity had a higher impact on work disability in low-educated cancer survivors than in high-educated and whether this impact differed when compared with individuals without cancer. Methods: Linkage of population-based public health survey data and the Danish Cancer Registry formed two groups: cancer survivors (n = 3,514) and [...]

Menée aux Etats-Unis notamment à partir des données d'un registre des cancers portant sur 4 768 patients militaires atteints d'un cancer du poumon non à petites cellules, cette étude analyse l'association entre la présence de comorbidités et le stade du cancer au diagnostic

Comorbidity and stage at diagnosis among lung cancer patients in the US military health system

Lin, Jie ; McGlynn, Katherine A. ; Nations, Joel A. ; Shriver, Craig D. ; Zhu, Kangmin

Purpose : We investigated the association between comorbidities and stage at diagnosis among NSCLC patients in the US Military Health System (MHS), which provides universal health care to its beneficiaries. Methods : The linked data from the Department of Defense’s Central Cancer Registry (CCR) and the MHS Data Repository (MDR) were used. The study included 4768 patients with histologically confirmed primary NSCLC. Comorbid conditions were extracted from the MDR data. Comorbid conditions were [...]

Menée dans 195 pays et territoires, cette étude analyse l'évolution de l'incidence du cancer de la prostate et de la mortalité sur la période 1990-2017

Incidence and disease burden of prostate cancer from 1990 to 2017: Results from the Global Burden of Disease Study 2017

Zhai, Zhen ; Zheng, Yi ; Li, Na ; Deng, Yujiao ; Zhou, Linghui ; Tian, Tian ; Yang, Si ; Hao, Qian ; Song, Dingli ; Wu, Ying ; Zhang, Dai ; Dai, Zhijun ; Wang, Ziming

Background : The patterns of the incidence and mortality of prostate cancer (PC) have been changing over the years. In addition, the unclear etiology of PC necessitates further studies into the geographic distribution and age composition of patients with PC. This study was aimed at examining the patterns of the epidemiology of PC to help policymakers to allocate the limited resources of the health care system accordingly. Methods : Annual case data and age‐standardized rates (ASRs) were [...]

Menée aux Etats-Unis à l'aide de données 1997-2013 du registre des cancers portant sur 4 660 hommes atteints d'un cancer colorectal, cette étude analyse les facteurs liés à la survie en fonction de la zone d'habitation (rurale ou urbaine)

Rural–urban disparities in colorectal cancer survival and risk among men in Utah: a statewide population-based study

Rogers, Charles R. ; Blackburn, Brenna E. ; Huntington, Matthew ; Curtin, Karen ; Thorpe, Roland J. ; Rowe, Kerry ; Snyder, John ; Deshmukh, Vikrant ; Newman, Michael ; Fraser, Alison ; Smith, Ken ; Hashibe, Mia

Rural areas of the U.S. experience disproportionate colorectal cancer (CRC) death compared to urban areas. The authors aimed to analyze differences in CRC survival between rural and urban Utah men and investigate potential prognostic factors for survival among these men. A cohort of Utah men diagnosed with CRC between 1997 and 2013 was identified from the Utah Cancer Registry. Survival and prognostic factors were analyzed via 5-year CRC survival and Cox proportional hazards models, stratified [...]

Menée aux Etats-Unis à partir de données 2006-2015 du registre des cancers portant sur des patients atteints d'un carcinome métastatique à cellules rénales, cette étude analyse le taux de survie en fonction du type histologique (cellules claires ou non) et de l'origine ethnique

Racial and ethnic differences in survival in contemporary metastatic renal cell carcinoma patients, according to alternative treatment modalities

Luzzago, Stefano ; Palumbo, Carlotta ; Rosiello, Giuseppe ; Knipper, Sophie ; Pecoraro, Angela ; Nazzani, Sebastiano ; Tian, Zhe ; Musi, Gennaro ; Montanari, Emanuele ; Shariat, Shahrokh F. ; Saad, Fred ; Briganti, Alberto ; De Cobelli, Ottavio ; Karakiewicz, Pierre I.

Purpose: To test the association between African-American race and overall mortality (OM) rates in patients with metastatic renal cell carcinoma (mRCC). Methods: Within the Surveillance, Epidemiology, and End Results registry (2006–2015), we identified patients with clear cell (ccmRCC) and non-clear cell mRCC (non-ccmRCC). African-Americans, Caucasians, and Hispanics were identified. Stratification was made according to histology and treatments: (1) no treatment, (2) systemic therapy (ST), (3) [...]

Menée auprès de 666 femmes afro-américaines ayant été traitées pour un cancer du sein entre 2005 et 2010 (âge moyen : 55 ans ; durée médiane de suivi : 6,1 ans), cette étude analyse l'effet de l'âge (+ ou - de 40 ans) sur le type de traitements reçus, la survie globale et la survie sans progression

Breast cancer in young black women

Walsh, S. M. ; Zabor, E. C. ; Flynn, J. ; Stempel, M. ; Morrow, M. ; Gemignani, M. L.

Background : Young age at breast cancer diagnosis is associated with negative prognostic outcomes, and breast cancer in black women often manifests at a young age. This study evaluated the effect of age on breast cancer management and outcomes in black women. Methods : This was a retrospective cohort study of all black women treated for invasive breast cancer between 2005 and 2010 at a specialized tertiary-care cancer centre. Clinical and treatment characteristics were compared by age. [...]

Menée aux Etats-Unis sur la période 2008-2015 auprès de 2 779 femmes atteintes de lésions cervicales intra-épithéliales de haut grade (âge : 21-29 ans), cette étude analyse la proportion de lésions associées au papillomavirus humain 16/18, en fonction de l'âge, de la localisation géographique de résidence, de l'origine ethnique et du niveau de vie

Human Papillomavirus 16/18-Associated Cervical Lesions: Differences by Area-Based Measures of Race and Poverty

Brackney, Monica M. ; Gargano, Julia W. ; Hannagan, Susan E. ; Meek, James ; Querec, Troy D. ; Niccolai, Linda M.

Introduction : This analysis evaluates trends in cervical lesions with human papillomavirus 16/18 detected by area-based measures of race, ethnicity, and poverty during 2008–2015. Methods : Trends in the proportion of lesions with human papillomavirus 16/18 detected among residents of New Haven County, Connecticut were examined by area-based measures of race, ethnicity, and poverty. Area-based measures are aggregate descriptors of census tract characteristics useful for measuring differences in [...]

Menée aux Etats-Unis à partir de données portant sur 525 740 patients atteints d'un cancer de la tête et du cou (âge moyen : 63,3 ans ; 70% d'hommes), cette étude analyse l'association entre le type d'établissement où sont administrés les traitements et la survie globale

Association of Type of Treatment Facility With Overall Survival After a Diagnosis of Head and Neck Cancer

Carey, Ryan M. ; Fathy, Ramie ; Shah, Ravi R. ; Rajasekaran, Karthik ; Cannady, Steven B. ; Newman, Jason G. ; Ibrahim, Said A. ; Brant, Jason A.

Patients with head and neck cancer receive care at academic comprehensive cancer programs (ACCPs), integrated network cancer programs (INCPs), comprehensive community cancer programs (CCCPs), and community cancer programs (CCPs). The type of treatment facility may be associated with overall survival.To examine whether type of treatment facility is associated with overall survival after a diagnosis of head and neck cancer.This population-based retrospective cohort study included patients from [...]