Menée à l'aide de données portant sur 188 052 individus (âge : 45-75 ans ; 45% d'hommes ; durée moyenne de suivi : 16,7 ans), cette étude analyse les disparités, en fonction du sexe et des sous-sites anatomiques, dans le risque de cancer colorectal associé au tabagisme (4 879 cas)

Smoking and Risk of Colorectal Cancer may differ by Anatomical Subsite and Sex

Gram, Inger T ; Park, Song-Yi ; Wilkens, Lynne R ; Haiman, Christopher A ; Le Marchand, Loic

The purpose of this study was to examine if the increased risk of colorectal cancer due to cigarette smoking differed by anatomical subsite and sex. We analyzed data from 188,052 participants (45% men, aged 45-75 years), who were enrolled in the Multiethnic Cohort Study in 1993-1996. During a mean follow-up of 16.7 years, we identified 4,879 incident cases of invasive colorectal adenocarcinoma. In multivariate Cox regression models, compared with never smokers of the same sex, male ever smokers [...]

Menée aux Etats-Unis à l'aide de données 2015 du registre sur la mortalité et de données nationales 1999–2014 portant sur un échantillon de 34 672 personnes (âge médian : 48 ans ; durée médiane de suivi : 7,8 ans ; 52% de femmes), cette étude analyse la mortalité toutes causes confondues et la mortalité par cancer attribuables à la consommation d'alcool (4 303 décès, 988 par cancer)

Trends in alcohol consumption in relation to cause-specific and all-cause mortality in the United States: a report from the NHANES linked to the US mortality registry

Ricci, Cristian ; Schutte, Aletta Elizabeth ; Schutte, Rudolph ; Smuts, Cornelius Matheus ; Pieters, Marlien

Excessive alcohol use is the third leading cause of mortality in the United States, where alcohol use consistently increased over the last decades. This trend is currently maintained, despite regulatory policies aimed to counteract it. While the increased health risks resulting from alcohol use are evident, some open questions regarding alcohol use and its consequences in the US population remain.The current work aims to evaluate the relation between alcohol consumption trends over a period of [...]

Menée au Danemark auprès de 123 228 témoins et de 5 078 enfants atteints d'un cancer diagnostiqué entre 1968 et 2016 (âge : moins de 17 ans), cette étude analyse l'association entre une exposition professionnelle de leurs parents à la poussière d'origine animale (élevage ou autre exposition) et le risque de développer la maladie

Occupational livestock or animal dust exposure and offspring cancer risk in Denmark, 1968–2016

Hall, Clinton ; Hansen, Johnni ; von Ehrenstein, Ondine S. ; He, Di ; Olsen, Jørn ; Ritz, Beate ; Heck, Julia E.

Objective: To examine associations with occupational livestock or other animal dust exposure and offspring cancer risk. Methods: In this population-based case–control study of Danish children aged < 17 years old, 5078 childhood cancer cases diagnosed 1968–2016 were matched to cancer-free controls by birth year and sex (n = 123,228). Occupational livestock or animal dust exposure was identified using a job-exposure matrix. We employed multivariable conditional logistic regression models to [...]

Menée en Chine auprès de 3 300 patients atteints d'échinococcose hydatique et de 815 patients atteints d'un carcinome hépatocellulaire, cette étude analyse l'effet de la co-existence des 2 maladies sur la progression et la croissance tumorales

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Bo, Ran ; Yasen, Aimaiti ; Shao, Yingmei ; Zhang, Wenbao ; Lin, Renyong ; Jiang, Tiemin ; Wen, Hao ; Xiao, Hui ; Aji, Tuerganaili

Purpose : Co-existence of hepatocellular carcinoma (HCC) and cystic echinococcus (CE) is extremely rare. Echinococcus granulosus may exhibit a protective effect against cancer. Herein, this study aimed to evaluate the possible effects of echinococcal infection on HCC patients. Methods : Three thousand three hundred hepatic CE patients and 815 HCC patients were retrospectively reviewed between January 2010 and December 2018 in Xinjiang, China, and these patients were 1:5 matched according to [...]

Menée en Corée auprès de 3 156 patients atteints d'une hépatite B chronique sous traitement par entecavir ou ténofovir (âge médian : 49,6 ans ; 62% d'hommes), cette étude analyse l'incidence du carcinome hépatocellulaire pendant et après 5 années de traitement antiviral

Hepatocellular carcinoma risk steadily persists over time despite long-term antiviral therapy for hepatitis B: A multicenter study

Kim, Seung Up ; Seo, Yeon Seok ; Lee, Han Ah ; Kim, Mi Na ; Lee, Eun Ju ; Shin, Hye Jung ; Lee, Yu Rim ; Lee, Hye Won ; Park, Jun Young ; Kim, Do Young ; Ahn, Sang Hoon ; Han, Kwang-Hyub ; Um, Soon Ho ; Tak, Won Young ; Kweon, Young Oh ; Kim, Beom Kyung ; Park, Soo Young

Background: Long-term antiviral therapy (AVT) for chronic hepatitis B (CHB) reduces the risk of hepatocellular carcinoma (HCC). We assessed the temporal trends in the incidence of HCC over time during long-term AVT among Asian CHB patients. Methods: Patients with CHB receiving entecavir/tenofovir (ETV/TDF) as a first line antiviral were recruited from four academic hospitals in the Republic of Korea. We compared the incidence of HCC during and after the first 5 years of ETV/TDF treatment. [...]

Menée à l'aide d'une méthode de randomisation mendélienne, de données d'études d'association sur le génome entier et de données génétiques portant sur 360 838 individus, cette étude analyse l'association entre des maladies allergiques (asthme, eczéma) et le risque de cancer du sein (122 977 cas) ou de la prostate (79 148 cas)

Allergy, asthma, and the risk of breast and prostate cancer: a Mendelian randomization study

Jiang, Xia ; Dimou, Niki L. ; Zhu, Zhaozhong ; Bonilla, Carolina ; Lewis, Sarah J. ; Lindström, Sara ; Kraft, Peter ; Tsilidis, Konstantinos K. ; Martin, Richard M. ; the Practical, Cruk Bpc Caps ; Pegasus consortia

Purpose : The relationship of allergic diseases, such as asthma, hay fever, and eczema, with cancer is under debate. Observational studies have reported conflicting findings, but such studies are susceptible to confounding and reverse causation. Understanding the potential role of allergy in carcinogenesis may shed new light on the biological mechanisms underpinning intrinsic immunity and cancer. Methods : We conducted a Mendelian randomization study, using germline genetic variants as [...]

A partir d'une recherche systématique de la littérature publiée jusqu'en décembre 2018 (7 articles ; 1 213 727 patients), cette méta-analyse évalue l'effet d'une chirurgie bariatrique sur le risque de développer un cancer colorectal chez les personnes obèses

Role of bariatric surgery in reducing the risk of colorectal cancer: a meta-analysis

Almazeedi, S. ; El-Abd, R. ; Al-Khamis, A. ; Albatineh, A. N. ; Al-Sabah, S.

Background : Obesity increases the risk of multiple co-morbidities such as type 2 diabetes, cardiovascular disease and most cancers, including colorectal cancer. Currently, the literature presents conflicting results regarding the protective effects of bariatric surgery on the incidence of colorectal cancer. This meta-analysis was conducted to investigate the effect of bariatric surgery on the risk of developing colorectal cancer in obese individuals. Methods : Ovid Embase, Ovid MEDLINE, [...]

Menée en Chine à l'aide de données portant sur 2 079 037 enfants nés entre 2004 et 2014, cette étude analyse l'association entre des facteurs démographiques ou gestationnels et le risque de cancer (1 900 cas), par localisation

Gestational risk factors and childhood cancers: a cohort study in Taiwan

Heck, Julia E ; Lee, Pei-Chen ; Wu, Chia-Kai ; Tsai, Hsin-Yun ; Ritz, Beate ; Arah, Onyebuchi A. ; Li, Chung-Yi

Gestational risk factors such as birth weight, gestational age, and parity have been repeatedly found to be related to pediatric cancers, but few reports have emerged from Asian countries. Here we report on demographic and gestational factors in a Taiwanese cohort. This study included all children born in Taiwan 2004–2014 for whom there was a birth record (N = 2,079,037), of which 1900 children had been diagnosed with cancer prior to age 12. We conducted multivariable hazard regression to [...]

Menée en Corée à partir de données 2009-2013 portant sur 223 138 individus sains (durée totale de suivi : 978 357 personnes-années), cette étude analyse l'association entre le nombre de composants du syndrome métabolique et le risque de cancer du pancréas (381 cas)

Metabolic syndrome, metabolic components, and their relation to the risk of pancreatic cancer

Park, Sung Keun ; Oh, Chang-Mo ; Kim, Min-Ho ; Ha, Eunhee ; Choi, Yong-Sung ; Ryoo, Jae-Hong

Background: Components of the metabolic syndrome (MetS), such as elevated fasting glucose levels and abdominal obesity, have been suggested as potential risk factors for pancreatic cancer. However, data are still insufficient to assure the influence of MetS on incident pancreatic cancer. The objective of the current study was to investigate the association between MetS, metabolic components, and the risk of pancreatic cancer. Methods: In the Korea National Health Information Database, 223,138 [...]

Menée au Danemark à l'aide de données portant sur 301 418 personnes nées entre 1930 et 1985, cette étude analyse l'association entre le poids à la naissance, l'indice de masse corporelle et la taille mesurés à 7 et 13 ans et le risque de carcinome à cellules rénales (1 010 cas), en fonction du sexe

Early life body size in relation to risk of renal cell carcinoma in adulthood: a Danish observational cohort study

Jensen, Britt Wang ; Meyle, Kathrine Damm ; Madsen, Kirsten ; Sørensen, Thorkild I. A. ; Baker, Jennifer Lyn

Adult obesity increases risks of renal cell carcinoma (RCC). This study investigated if birth weight, child body mass index (BMI) and height are associated with adult RCC. The study included 301,418 children (152,569 boys) from the Copenhagen School Health Records Register born 1930–1985 with measured weights and heights at ages 7 to 13 years. Birth weight was obtained by parental report. BMI and height were transformed to z-scores, and BMI was categorized as normal BMI or overweight. RCC was [...]

Menée à partir de données de 17 études internationales portant au total sur 628 463 femmes (âge médian à l'inclusion : 39,4 ans ; durée médiane de suivi : 10 ans), cette étude analyse l'association entre une évolution du poids (à partir de 18 ans) et le risque de développer un cancer du sein avant la ménopause (10 886 cas), en général et par sous-types

Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women

Schoemaker, Minouk J ; Nichols, Hazel B ; Wright, Lauren B ; Brook, Mark N ; Jones, Michael E ; O'Brien, Katie M ; Adami, Hans-Olov ; Baglietto, Laura ; Bernstein, Leslie ; Bertrand, Kimberly A ; Boutron-Ruault, Marie-Christine ; Chen, Yu ; Connor, Avonne E ; Dossus, Laure ; Eliassen, A Heather ; Giles, Graham G ; Gram, Inger T ; Hankinson, Susan E ; Kaaks, Rudolf ; Key, Timothy J ; Kirsh, Victoria A ; Kitahara, Cari M ; Larsson, Susanna C ; Linet, Martha ; Ma, Huiyan ; Milne, Roger L ; Ozasa, Kotaro ; Palmer, Julie R ; Riboli, Elio ; Rohan, Thomas E ; Sacerdote, Carlotta ; Sadakane, Atsuko ; Sund, Malin ; Tamimi, Rulla M ; Trichopoulou, Antonia ; Ursin, Giske ; Visvanathan, Kala ; Weiderpass, Elisabete ; Willett, Walter C ; Wolk, Alicja ; Zeleniuch-Jacquotte, Anne ; Sandler, Dale P ; Swerdlow, Anthony J

Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors, and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were [...]