Immune therapeutic strategies for the senescent tumor microenvironment

Cet article présente les avancées récentes concernant les approches immunomodulatrices permettant de cibler les cellules sénescentes du microenvironnement tumoral pour contrer la résistance thérapeutique

Résumé en anglais

Senescent cells can either to promote immunosuppressive tumor microenvironment or facilitate immune surveillance. Despite the revolutionary impact of cancer immunotherapy, durable responses in solid tumors, particularly in advanced stages, remain limited. Recent studies have shed light on the influence of senescent status within the tumor microenvironment (TME) on therapy resistance and major efforts are needed to overcome these challenges. This review summarizes recent advancements in targeting cellular senescence, with a particular focus on immunomodulatory approaches on the hallmarks of cellular senescence.